A0A5C3QKU4 protein (Pterula gracilis) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

A0A5C3QKU4

Mitochondrial protein Pet127-domain-containing protein. (771 aa)

Predicted Functional Partners:

A0A5C3Q176

0.801

A0A5C3QIU5

0.601

A0A5C3Q8S3

0.595

A0A5C3R186

0.595

A0A5C3R085

0.537

A0A5C3QKF5

0.523

A0A5C3QY86

0.512

A0A5C3QH16

0.511

A0A5C3QUJ8

0.504

A0A5C3QRK3

0.503

Your Current Organism:

Pterula gracilis

NCBI taxonomy Id: 1884261
Other names: Hirsutella gracilis, P. gracilis, Pistillaria gracilis, Typhula gracilis

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A5C3Q176	A0A5C3QKU4	Sister chromatid cohesion protein.	Mitochondrial protein Pet127-domain-containing protein.	0.801
A0A5C3Q8S3	A0A5C3QKU4	Uncharacterized protein.	Mitochondrial protein Pet127-domain-containing protein.	0.595
A0A5C3Q8S3	A0A5C3QRK3	Uncharacterized protein.	Ubiquitin-conjugating enzyme 9; Belongs to the ubiquitin-conjugating enzyme family.	0.756
A0A5C3Q8S3	A0A5C3QUJ8	Uncharacterized protein.	Ubiquitin-domain-containing protein.	0.870
A0A5C3Q8S3	A0A5C3R085	Uncharacterized protein.	Mov34-domain-containing protein.	0.819
A0A5C3QH16	A0A5C3QKU4	RNA polymerase III transcription factor IIIC subunit-domain-containing protein.	Mitochondrial protein Pet127-domain-containing protein.	0.511
A0A5C3QH16	A0A5C3QY86	RNA polymerase III transcription factor IIIC subunit-domain-containing protein.	Uncharacterized protein.	0.997
A0A5C3QIU5	A0A5C3QKU4	EGF-like domain-containing protein.	Mitochondrial protein Pet127-domain-containing protein.	0.601
A0A5C3QKF5	A0A5C3QKU4	P-loop containing nucleoside triphosphate hydrolase protein.	Mitochondrial protein Pet127-domain-containing protein.	0.523
A0A5C3QKU4	A0A5C3Q176	Mitochondrial protein Pet127-domain-containing protein.	Sister chromatid cohesion protein.	0.801
A0A5C3QKU4	A0A5C3Q8S3	Mitochondrial protein Pet127-domain-containing protein.	Uncharacterized protein.	0.595
A0A5C3QKU4	A0A5C3QH16	Mitochondrial protein Pet127-domain-containing protein.	RNA polymerase III transcription factor IIIC subunit-domain-containing protein.	0.511
A0A5C3QKU4	A0A5C3QIU5	Mitochondrial protein Pet127-domain-containing protein.	EGF-like domain-containing protein.	0.601
A0A5C3QKU4	A0A5C3QKF5	Mitochondrial protein Pet127-domain-containing protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.523
A0A5C3QKU4	A0A5C3QRK3	Mitochondrial protein Pet127-domain-containing protein.	Ubiquitin-conjugating enzyme 9; Belongs to the ubiquitin-conjugating enzyme family.	0.503
A0A5C3QKU4	A0A5C3QUJ8	Mitochondrial protein Pet127-domain-containing protein.	Ubiquitin-domain-containing protein.	0.504
A0A5C3QKU4	A0A5C3QY86	Mitochondrial protein Pet127-domain-containing protein.	Uncharacterized protein.	0.512
A0A5C3QKU4	A0A5C3R085	Mitochondrial protein Pet127-domain-containing protein.	Mov34-domain-containing protein.	0.537
A0A5C3QKU4	A0A5C3R186	Mitochondrial protein Pet127-domain-containing protein.	Skp1 family, dimerization domain-containing protein; Belongs to the SKP1 family.	0.595
A0A5C3QRK3	A0A5C3Q8S3	Ubiquitin-conjugating enzyme 9; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.756

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.618

expected number of edges:

14

PPI enrichment p-value:

5.26e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017183

Peptidyl-diphthamide biosynthetic process from peptidyl-histidine

5 of 8

2.68

4.35

5.72e-09

GO:0006417

Regulation of translation

7 of 140

1.58

2.47

7.55e-08

GO:0042256

Mature ribosome assembly

2 of 6

2.41

1.19

0.0064

GO:0002926

tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation

2 of 6

2.41

1.19

0.0064

GO:0044249

Cellular biosynthetic process

8 of 1176

0.72

0.54

0.0035

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003924

GTPase activity

6 of 93

1.69

2.35

1.42e-06

GO:0005525

GTP binding

6 of 120

1.58

2.09

3.09e-06

GO:0090560

2-(3-amino-3-carboxypropyl)histidine synthase activity

2 of 2

2.88

1.59

0.0013

GO:0043022

Ribosome binding

3 of 24

1.98

1.57

0.00076

GO:0034986

Iron chaperone activity

2 of 4

2.58

1.39

0.0028

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5260

Synthesis of diphthamide-EEF2, and Ribosome disassembly

6 of 7

2.82

6.14

2.32e-12

CL:5230

tRNA wobble uridine modification, and Synthesis of diphthamide-EEF2

7 of 25

2.33

5.51

2.32e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5358493

Synthesis of diphthamide-EEF2

6 of 8

2.76

6.07

2.54e-12

MAP-163841

Gamma carboxylation, hypusine formation and arylsulfatase activation

6 of 16

2.46

5.23

3.15e-11

MAP-392499

Metabolism of proteins

8 of 806

0.88

0.78

0.00028

MAP-597592

Post-translational protein modification

6 of 520

0.95

0.7

0.0046

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070652

HAUS complex

2 of 5

2.49

0.82

0.0317

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0251

Elongation factor

4 of 15

2.31

2.99

1.40e-06

KW-0949

S-adenosyl-L-methionine

3 of 43

1.73

1.3

0.0019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00009

Elongation factor Tu GTP binding domain

6 of 12

2.58

5.53

1.51e-11

PF03144

Elongation factor Tu domain 2

3 of 9

2.41

2.02

0.00016

PF01866

Putative diphthamide synthesis protein

2 of 2

2.88

1.42

0.0027

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042265

Diphthamide synthesis DPH1/DPH2, domain 3

2 of 2

2.88

1.22

0.0061

IPR042263

Diphthamide synthesis DPH1/DPH2, domain 1

2 of 2

2.88

1.22

0.0061

IPR016435

Diphthamide synthesis DPH1/DPH2

2 of 2

2.88

1.22

0.0061

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00838

Elongation factor G C-terminus

5 of 5

2.88

5.35

9.91e-11

SM00889

Elongation factor G, domain IV

3 of 3

2.88

2.89

4.99e-06

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