SMG37046.1 protein (Arenibacter troitsensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SMG37046.1

Neutral/alkaline non-lysosomal ceramidase, N-terminal. (466 aa)

Predicted Functional Partners:

SMG37036.1

0.827

SMG37062.1

0.824

SMG36455.1

0.808

SMG52514.1

0.808

SMG49842.1

0.772

SMG37034.1

0.768

zwf

0.759

SMG37026.1

0.726

SMG37031.1

0.726

SMG19793.1

0.723

Your Current Organism:

Arenibacter troitsensis

NCBI taxonomy Id: 188872
Other names: A. troitsensis, Arenibacter trinitatis, Arenibacter troitsensis Nedashkovskaya et al. 2003, DSM 19835, JCM 11736, KMM 3674, NBRC 101532

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SMG19793.1	SMG37046.1	SAMN03080602_01260	SAMN03080602_02586	Starch-binding associating with outer membrane.	Neutral/alkaline non-lysosomal ceramidase, N-terminal.	0.723
SMG19793.1	SMG37062.1	SAMN03080602_01260	SAMN03080602_02587	Starch-binding associating with outer membrane.	Hypothetical protein.	0.709
SMG19793.1	SMG49842.1	SAMN03080602_01260	SAMN03080602_03889	Starch-binding associating with outer membrane.	Hypothetical protein.	0.770
SMG36455.1	SMG37046.1	SAMN03080602_02502	SAMN03080602_02586	N-acetylglucosamine-6-phosphate deacetylase.	Neutral/alkaline non-lysosomal ceramidase, N-terminal.	0.808
SMG37026.1	SMG37031.1	SAMN03080602_02582	SAMN03080602_02583	Acetyl esterase/lipase.	Acetyl esterase/lipase.	0.779
SMG37026.1	SMG37034.1	SAMN03080602_02582	SAMN03080602_02584	Acetyl esterase/lipase.	Alpha-1,2-mannosidase, putative.	0.732
SMG37026.1	SMG37036.1	SAMN03080602_02582	SAMN03080602_02585	Acetyl esterase/lipase.	Predicted neuraminidase (sialidase).	0.732
SMG37026.1	SMG37046.1	SAMN03080602_02582	SAMN03080602_02586	Acetyl esterase/lipase.	Neutral/alkaline non-lysosomal ceramidase, N-terminal.	0.726
SMG37026.1	SMG37062.1	SAMN03080602_02582	SAMN03080602_02587	Acetyl esterase/lipase.	Hypothetical protein.	0.706
SMG37031.1	SMG37026.1	SAMN03080602_02583	SAMN03080602_02582	Acetyl esterase/lipase.	Acetyl esterase/lipase.	0.779
SMG37031.1	SMG37034.1	SAMN03080602_02583	SAMN03080602_02584	Acetyl esterase/lipase.	Alpha-1,2-mannosidase, putative.	0.732
SMG37031.1	SMG37036.1	SAMN03080602_02583	SAMN03080602_02585	Acetyl esterase/lipase.	Predicted neuraminidase (sialidase).	0.732
SMG37031.1	SMG37046.1	SAMN03080602_02583	SAMN03080602_02586	Acetyl esterase/lipase.	Neutral/alkaline non-lysosomal ceramidase, N-terminal.	0.726
SMG37031.1	SMG37062.1	SAMN03080602_02583	SAMN03080602_02587	Acetyl esterase/lipase.	Hypothetical protein.	0.706
SMG37034.1	SMG37026.1	SAMN03080602_02584	SAMN03080602_02582	Alpha-1,2-mannosidase, putative.	Acetyl esterase/lipase.	0.732
SMG37034.1	SMG37031.1	SAMN03080602_02584	SAMN03080602_02583	Alpha-1,2-mannosidase, putative.	Acetyl esterase/lipase.	0.732
SMG37034.1	SMG37036.1	SAMN03080602_02584	SAMN03080602_02585	Alpha-1,2-mannosidase, putative.	Predicted neuraminidase (sialidase).	0.800
SMG37034.1	SMG37046.1	SAMN03080602_02584	SAMN03080602_02586	Alpha-1,2-mannosidase, putative.	Neutral/alkaline non-lysosomal ceramidase, N-terminal.	0.768
SMG37034.1	SMG37062.1	SAMN03080602_02584	SAMN03080602_02587	Alpha-1,2-mannosidase, putative.	Hypothetical protein.	0.746
SMG37036.1	SMG37026.1	SAMN03080602_02585	SAMN03080602_02582	Predicted neuraminidase (sialidase).	Acetyl esterase/lipase.	0.732

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.887

expected number of edges:

16

PPI enrichment p-value:

2.23e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045892

Negative regulation of transcription, DNA-templated

8 of 599

1.23

1.45

5.61e-06

GO:0051172

Negative regulation of nitrogen compound metabolic process

10 of 1220

1.01

1.12

2.62e-06

GO:0070544

Histone H3-K36 demethylation

2 of 7

2.56

1.12

0.0090

GO:0035518

Histone H2A monoubiquitination

2 of 8

2.5

1.09

0.0102

GO:0010605

Negative regulation of macromolecule metabolic process

10 of 1414

0.95

1.0

5.61e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140680

Histone H3-di/monomethyl-lysine-36 demethylase activity

2 of 3

2.92

1.18

0.0074

GO:0003682

Chromatin binding

5 of 314

1.3

0.89

0.0067

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031519

PcG protein complex

4 of 23

2.34

2.75

4.85e-06

GO:0035102

PRC1 complex

3 of 7

2.73

2.47

2.89e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1795

PcG protein complex, and RNA binding Region

8 of 20

2.7

8.24

4.74e-17

CL:1799

PcG protein complex

5 of 15

2.62

4.78

6.52e-10

CL:1802

RAWUL domain RING finger- and WD40-associated ubiquitin-like

3 of 5

2.88

2.81

7.19e-06

CL:18880

Alpha-macro-globulin thiol-ester bond-forming region, and Membrane attack complex

3 of 24

2.2

1.81

0.00034

CL:18918

Alpha-macro-globulin thiol-ester bond-forming region, and CUB domain

2 of 5

2.7

1.38

0.0031

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8939243

RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

5 of 27

2.37

3.76

3.60e-08

MAP-8943724

Regulation of PTEN gene transcription

5 of 40

2.2

3.39

1.09e-07

MAP-2559580

Oxidative Stress Induced Senescence

5 of 57

2.04

3.01

3.81e-07

MAP-6807070

PTEN Regulation

5 of 75

1.92

2.7

1.06e-06

MAP-3108214

SUMOylation of DNA damage response and repair proteins

4 of 41

2.09

2.52

7.47e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031519

PcG protein complex

3 of 20

2.28

1.6

0.00096

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF17208

RNA binding Region

2 of 2

3.1

1.23

0.0061

PF16207

RAWUL domain RING finger- and WD40-associated ubiquitin-like

2 of 4

2.8

1.17

0.0077

PF12140

SLED domain

2 of 5

2.7

1.16

0.0077

PF02008

CXXC zinc finger domain

2 of 5

2.7

1.16

0.0077

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00561

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

2 of 9

2.45

0.9

0.0223

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About