Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ANB05170.1Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)    
Predicted Functional Partners:
metH
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.973
mdeA
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
0.942
ybgG
Homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.940
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 0.934
cysA
Cystathionine gamma-lyase; Catalyzes the formation of cysteine and 2-oxobutanoate from cystathionine; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 
0.926
metG
methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
   
 
 0.915
ANB04751.1
Fused response regulator/thioredoxin-disulfide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.913
ANB04932.1
Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.910
trxB
Thioredoxin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.905
cbs
Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.893
Your Current Organism:
Streptomyces ambofaciens
NCBI taxonomy Id: 1889
Other names: ATCC 23877, BCRC 11857, CBS 616.68, CCRC 11857, CCRC:11857, CECT 3101, DSM 40053, IFO 12836, ISP 5053, JCM 4204, JCM 4618, KCTC 9111, NBRC 12836, NRRL 2420, NRRL B-2516, NRRL-ISP 5053, S. ambofaciens
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