Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pafAPup--protein ligase; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. (453 aa)    
Predicted Functional Partners:
prcA
Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family.
   
 0.950
prcB
Proteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family.
 
   
 0.924
arc
Proteasome ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
 
   
 0.923
pup
Ubiquitin; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
 
  
 0.884
ANB05478.1
MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.877
ANB05473.1
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.794
ANB05479.1
LacI family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.771
ANB05474.1
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.767
ANB07440.1
Peptidylprolyl isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.760
ANB05476.1
Peptidylprolyl isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.745
Your Current Organism:
Streptomyces ambofaciens
NCBI taxonomy Id: 1889
Other names: ATCC 23877, BCRC 11857, CBS 616.68, CCRC 11857, CCRC:11857, CECT 3101, DSM 40053, IFO 12836, ISP 5053, JCM 4204, JCM 4618, KCTC 9111, NBRC 12836, NRRL 2420, NRRL B-2516, NRRL-ISP 5053, S. ambofaciens
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