| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANB05231.1 | ANB06052.1 | SAM40697_1271 | SAM40697_2092 | MerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.769 |
| ANB05231.1 | ANB09003.1 | SAM40697_1271 | SAM40697_5046 | MerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | dUTPase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.773 |
| ANB05231.1 | glnE | SAM40697_1271 | SAM40697_2122 | MerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.690 |
| ANB05231.1 | rbpA | SAM40697_1271 | SAM40697_1311 | MerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. | 0.778 |
| ANB06052.1 | ANB05231.1 | SAM40697_2092 | SAM40697_1271 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | MerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.769 |
| ANB06052.1 | ANB09003.1 | SAM40697_2092 | SAM40697_5046 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | dUTPase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.769 |
| ANB06052.1 | glnE | SAM40697_2092 | SAM40697_2122 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.712 |
| ANB06052.1 | rbpA | SAM40697_2092 | SAM40697_1311 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. | 0.770 |
| ANB09003.1 | ANB05231.1 | SAM40697_5046 | SAM40697_1271 | dUTPase; Derived by automated computational analysis using gene prediction method: Protein Homology. | MerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.773 |
| ANB09003.1 | ANB06052.1 | SAM40697_5046 | SAM40697_2092 | dUTPase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.769 |
| ANB09003.1 | glnE | SAM40697_5046 | SAM40697_2122 | dUTPase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.691 |
| ANB09003.1 | rbpA | SAM40697_5046 | SAM40697_1311 | dUTPase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. | 0.774 |
| crgA | glnE | SAM40697_3449 | SAM40697_2122 | Hypothetical protein; Involved in cell division; Belongs to the CrgA family. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.781 |
| glnA | glnA-2 | SAM40697_2094 | SAM40697_2129 | Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. | 0.702 |
| glnA | glnD | SAM40697_2094 | SAM40697_4837 | Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | protein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.912 |
| glnA | glnE | SAM40697_2094 | SAM40697_2122 | Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.862 |
| glnA | glnK | SAM40697_2094 | SAM40697_4836 | Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Transcriptional regulator; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.822 |
| glnA | gltB | SAM40697_2094 | SAM40697_1921 | Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.978 |
| glnA-2 | glnA | SAM40697_2129 | SAM40697_2094 | Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. | Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.702 |
| glnA-2 | glnD | SAM40697_2129 | SAM40697_4837 | Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. | protein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.757 |
STRING v12.5 is now available!
