Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
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[Homology]
Score
fbiBF420-0--gamma-glutamyl ligase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. (447 aa)    
Predicted Functional Partners:
cofD
2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
 
 
 0.999
cofC
2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
 
   
 0.902
ANB06769.1
Cysteine dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.828
cgc19
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
  
 
 0.780
ANB06772.1
3-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.778
ANB09124.1
F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.771
ANB07768.1
Cation-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.745
ANB05506.1
Luciferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.739
ANB08445.1
NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      0.736
ANB10036.1
Nitroreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.719
Your Current Organism:
Streptomyces ambofaciens
NCBI taxonomy Id: 1889
Other names: ATCC 23877, BCRC 11857, CBS 616.68, CCRC 11857, CCRC:11857, CECT 3101, DSM 40053, IFO 12836, ISP 5053, JCM 4204, JCM 4618, KCTC 9111, NBRC 12836, NRRL 2420, NRRL B-2516, NRRL-ISP 5053, S. ambofaciens
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