close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
afsR-2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (61 aa)    
Predicted Functional Partners:
actII
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.650
afsQ-2
Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.589
abaB
LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family.
      
 0.589
cutS
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.589
crp
Crp/Fnr family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.574
afsR
Regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.525
pstS
Phosphate-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import; Belongs to the PstS family.
      
 0.518
glnII
Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.502
glnD
protein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
      
 0.457
dasR
GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.450
Your Current Organism:
Streptomyces ambofaciens
NCBI taxonomy Id: 1889
Other names: ATCC 23877, BCRC 11857, CBS 616.68, CCRC 11857, CCRC:11857, CECT 3101, DSM 40053, IFO 12836, ISP 5053, JCM 4204, JCM 4618, KCTC 9111, NBRC 12836, NRRL 2420, NRRL B-2516, NRRL-ISP 5053, S. ambofaciens
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.