Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AMP98161.1Cysteine desulfurase; Pfam:pfam00266 Aminotransferase class-V. (384 aa)    
Predicted Functional Partners:
AMP99440.1
Scaffolding protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
 0.979
AMQ01356.1
Hypothetical protein; Pfam:pfam00899 ThiF family.
   
 0.975
iscS
Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
  
  
 
0.918
AMP99957.1
Cysteine desulfurase; Pfam:pfam00266 Aminotransferase class-V.
  
  
 
0.907
AMP98160.1
MBL fold metallo-hydrolase; Pfam:pfam00753 Metallo-beta-lactamase superfamily.
   
 
 0.675
AMP99441.1
Iron-sulfur cluster assembly accessory protein; Pfam:pfam01521 Iron-sulphur cluster biosynthesis; Belongs to the HesB/IscA family.
 
 
 0.646
AMP97110.1
Molecular chaperone Hsc20; Pfam:pfam00226 DnaJ domain.
  
 0.635
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.602
AMQ01184.1
Pfam:pfam02082 Transcriptional regulator.
 
  
 0.594
AMQ01896.1
[Fe-S]-binding protein; Pfam:pfam01521 Iron-sulphur cluster biosynthesis; Belongs to the HesB/IscA family.
  
 
 0.588
Your Current Organism:
Pedobacter cryoconitis
NCBI taxonomy Id: 188932
Other names: DSM 14825, LMG 21415, LMG:21415, P. cryoconitis, Pedobacter cryoconitis Margesin et al. 2003
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