Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sec11Signal sequence peptidase. (185 aa)    
Predicted Functional Partners:
secD
Protein-export membrane protein SecD; Involved in protein export.
 
  
 0.938
atpE
H(+)-transporting ATP synthase, subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane.
 
  
 0.869
srp54
Signal recognition particle, 54 kDa protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
  
  
 0.829
MA_2449
Sterol-regulatory element-binding protein intramembrane protease.
 
  
 0.786
atpF
H(+)-transporting ATP synthase, subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane.
 
 
  0.772
MA_0114
Conserved hypothetical protein.
  
   
 0.758
atpC
H(+)-transporting ATP synthase, subunit C.
 
  
 0.756
atpC-2
H(+)-transporting ATP synthase, subunit C; Produces ATP from ADP in the presence of a proton gradient across the membrane.
 
  
 0.756
polB
DNA-directed DNA polymerase, subunit 1; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
 
     0.747
MA_3753
Transmembrane oligosaccharyl transferase.
  
  
 0.740
Your Current Organism:
Methanosarcina acetivorans
NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A
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