Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mtmB1Monomethylamine methyltransferase; Catalyzes the transfer of the methyl group from monomethylamine to the corrinoid cofactor of MtmC. (458 aa)    
Predicted Functional Partners:
mtmC1
Monomethylamine corrinoid protein; Acts as a methyl group carrier between MtmB and MtbA.
    
  0.972
mttB
Trimethylamine methyltransferase; Catalyzes the transfer of a methyl group from trimethylamine to the corrinoid cofactor of MttC.
 
  
 0.941
pylS
Predicted protein; Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
 
   
 0.934
mtbA
methylcobalamin:CoM methyltransferase isozyme A; Methyltransferase involved in methanogenesis from methylamines methanol pathway. Catalyzes the transfer of the methyl group from the methylated corrinoid protein MtmC (MtmC1 or MtmC2) to coenzyme M, forming the substrate for coenzyme-B sulfoethylthiotransferase (By similarity); Belongs to the uroporphyrinogen decarboxylase family. MtbA/MtaA subfamily.
 
  
  0.927
mtmC
Monomethylamine corrinoid protein; Acts as a methyl group carrier between MtmB and MtbA.
    
  0.902
mtmB2
Monomethylamine methyltransferase; Catalyzes the transfer of the methyl group from monomethylamine to the corrinoid cofactor of MtmC.
  
  
0.901
mttB-2
Trimethylamine methyltransferase; Catalyzes the transfer of a methyl group from trimethylamine to the corrinoid cofactor of MttC.
 
  
 0.882
mtbB
Dimethylamine methyltransferase; Catalyzes the transfer of a methyl group from dimethylamine to the corrinoid cofactor of MtbC.
    
 0.865
pylD
Predicted protein; Likely catalyzes the NAD(P)-dependent oxidative deamination of (3R)-3-methyl-D-ornithyl-N6-L-lysine, resulting in the formation of pyrrolysine after spontaneous dehydration and cyclization of the intermediate. Is required for the biosynthesis of pyrrolysine.
 
   
 0.855
pylC
Predicted protein; Likely catalyzes the ATP-dependent ligation between (2R,3R)- 3-methylornithine and L-lysine, leading to (3R)-3-methyl-D-ornithyl-N6- L-lysine. Is required for the biosynthesis of pyrrolysine. Belongs to the PylC family.
 
   
 0.853
Your Current Organism:
Methanosarcina acetivorans
NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A
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