Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
pylCPredicted protein; Likely catalyzes the ATP-dependent ligation between (2R,3R)- 3-methylornithine and L-lysine, leading to (3R)-3-methyl-D-ornithyl-N6- L-lysine. Is required for the biosynthesis of pyrrolysine. Belongs to the PylC family. (363 aa)    
Predicted Functional Partners:
pylD
Predicted protein; Likely catalyzes the NAD(P)-dependent oxidative deamination of (3R)-3-methyl-D-ornithyl-N6-L-lysine, resulting in the formation of pyrrolysine after spontaneous dehydration and cyclization of the intermediate. Is required for the biosynthesis of pyrrolysine.
 
  
 0.999
bioB
Biotin synthase; Catalyzes the isomerization of L-lysine to (2R,3R)-3- methylornithine via a radical-based mechanism (Probable). Is required for the biosynthesis of pyrrolysine; Belongs to the radical SAM superfamily. PylB family.
 
 
 0.999
pylS
Predicted protein; Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
 
   
 0.996
carA
Carbamoyl-phosphate synthase (glutamine-hydrolyzing), small subunit; Belongs to the CarA family.
  
 
 0.945
lysA
Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
  
 
 0.921
mttB
Trimethylamine methyltransferase; Catalyzes the transfer of a methyl group from trimethylamine to the corrinoid cofactor of MttC.
 
   
 0.880
mttB-2
Trimethylamine methyltransferase; Catalyzes the transfer of a methyl group from trimethylamine to the corrinoid cofactor of MttC.
 
   
 0.879
mtmB1
Monomethylamine methyltransferase; Catalyzes the transfer of the methyl group from monomethylamine to the corrinoid cofactor of MtmC.
 
   
 0.853
pyrD
Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
  
 
 0.849
pyrF
Orotidine-5-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
 
  
 0.833
Your Current Organism:
Methanosarcina acetivorans
NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A
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