Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
MA_0164Conserved hypothetical protein. (223 aa)    
Predicted Functional Partners:
MA_0165
Conserved hypothetical protein.
 
  
 0.998
MA_4551
Conserved hypothetical protein; Radical SAM methyltransferase that is responsible for the C(5)-methylation of 'Arg-285' of the methyl-coenzyme M reductase (MCR) subunit alpha McrA. This post-translational methylation, despite being not essential in vivo, plays a role for the stability and structural integrity of MCR.
  
   
 0.896
MA_3997
Conserved hypothetical protein; Belongs to the UPF0288 family.
  
   
 0.815
MA_4547
Methyl coenzyme M reductase, subunit gamma.
 
   
 0.783
mcrA
Methyl coenzyme M reductase, subunit alpha; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
 
   
 0.772
cmd-4
Carboxymuconolactone decarboxylase.
  
     0.608
MA_1981
Conserved hypothetical protein.
  
     0.584
MA_3992
Conserved hypothetical protein.
  
     0.579
MA_3996
Conserved hypothetical protein.
  
     0.573
MA_4549
Methyl coenzyme M reductase, subunit C.
 
     0.569
Your Current Organism:
Methanosarcina acetivorans
NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A
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