Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
matMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (398 aa)    
Predicted Functional Partners:
mat-2
Methionine adenosyltransferase.
  
  
 
0.905
MA_0053
Conserved hypothetical protein.
     
 0.903
MA_0054
Conserved hypothetical protein.
     
 0.903
metE
5-methyltetrahydropteroyltriglutamate homocysteine S-methyltransferase.
     
 0.903
mgl
Methionine gamma-lyase.
    
  0.902
MA_0148
Ribosomal RNA adenine dimethylase.
    
  0.901
metY
O-acetylhomoserine (thiol)-lyase.
     
  0.900
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
    0.765
hisA
N-(5-phospho-D-ribosylformimino)-5-amino-1-(5- phosphoribosyl)-4-imidazole carboxamide isomerase.
       0.695
hisB
Imidazoleglycerol-phosphate dehydrogenase.
       0.693
Your Current Organism:
Methanosarcina acetivorans
NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A
Server load: medium (48%) [HD]