Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MA_0538Peptidase family protein U32. (855 aa)    
Predicted Functional Partners:
MA_0537
c-Myc-responsive protein; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base; Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
       0.908
MA_0536
Predicted protein.
       0.793
MA_0707
caffeoyl-CoA O-methyltransferase.
 
  
 0.710
fpoC
F(420)H(2) dehydrogenase, subunit FpoC.
  
   0.660
fpoI
F(420)H(2) dehydrogenase, subunit FpoI.
  
 
 0.649
MA_0163
Conserved hypothetical protein.
       0.613
hisF
Imidazoleglycerol-phosphate synthase (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
       0.600
fpoD
F(420)H(2) dehydrogenase, subunit FpoD.
  
   0.563
fpoJ
F(420)H(2) dehydrogenase, subunit FpoJ.
 
   0.561
fpoH
F(420)H(2) dehydrogenase, subunit FpoH; Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2):heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples th [...]
  
   0.524
Your Current Organism:
Methanosarcina acetivorans
NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A
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