Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (305 aa)    
Predicted Functional Partners:
hmgA
hydroxymethylglutaryl-CoA reductase (NADPH); Belongs to the HMG-CoA reductase family.
 
 0.995
idi
Isopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
 
  
 0.990
MA_0603
Amino acid kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
 
   
 0.987
MA_0245
Conserved hypothetical protein.
 
  
  0.929
MA_0244
Conserved hypothetical protein; Belongs to the UPF0107 family.
 
  
  0.916
MA_0601
Conserved hypothetical protein; Belongs to the MEMO1 family.
 
     0.895
MA_4041
Acyl carrier protein synthase; Belongs to the thiolase-like superfamily. UPF0219 family.
 
  
 0.894
idsA
Bifunctional short chain isoprenyl diphosphate synthase; Belongs to the FPP/GGPP synthase family.
 
  
 0.892
rps2
Ribosomal protein S2p; Belongs to the universal ribosomal protein uS2 family.
 
   
 0.850
pheRS
phenylalanyl-tRNA synthetase, subunit alpha; Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
 
 
 0.813
Your Current Organism:
Methanosarcina acetivorans
NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A
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