Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MA_0641Conserved hypothetical protein. (467 aa)    
Predicted Functional Partners:
eif2A
Translation initiation factor 2, subunit alpha.
 
     0.905
pcrA
ATP-dependent DNA helicase.
    
 0.898
MA_0642
3-isopropylmalate dehydratase.
       0.892
nop10
Conserved hypothetical protein; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
       0.887
rps27e
Ribosomal protein S27e.
 
     0.880
rpl44e
Ribosomal protein L44e; Binds to the 23S rRNA.
       0.830
udg
uracil-DNA glycosylase.
     
 0.794
MA_2077
DNA-(apurinic or apyrimidinic site) lyase.
     
 0.792
MA_0462
Conserved hypothetical protein; Excises hypoxanthine, a deamination product of adenine, from double-stranded DNA. Acts on double-stranded DNA containing G/I, T/I, A/I and C/I base pairs, but not on single-stranded inosine-containing DNA. Has also minor xanthine DNA glycosylase activity. Lacks any detectable uracil-DNA glycosylase activity.
      
 0.791
nth
DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
     
 0.786
Your Current Organism:
Methanosarcina acetivorans
NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.