Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MA_06423-isopropylmalate dehydratase. (256 aa)    
Predicted Functional Partners:
eif2A
Translation initiation factor 2, subunit alpha.
 
    0.969
rpl44e
Ribosomal protein L44e; Binds to the 23S rRNA.
 
     0.967
nop10
Conserved hypothetical protein; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
 
     0.960
rps27e
Ribosomal protein S27e.
 
     0.958
priS
DNA primase; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play [...]
 
     0.903
MA_0641
Conserved hypothetical protein.
       0.892
MA_0647
Predicted protein.
 
     0.844
pcnA
Proliferating cell nuclear antigen; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
 
     0.801
polC
DNA-directed DNA polymerase, subunit 2; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
  
     0.718
nac
Conserved hypothetical protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.
 
     0.702
Your Current Organism:
Methanosarcina acetivorans
NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A
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