Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
lrpLeucine responsive regulatory protein. (163 aa)    
Predicted Functional Partners:
tyrB
Aromatic amino acid transferase.
 
   
 0.972
rps8e
Ribosomal protein S8e.
       0.899
MA_1588
Conserved hypothetical protein.
   
 
 0.780
hmgA
hydroxymethylglutaryl-CoA reductase (NADPH); Belongs to the HMG-CoA reductase family.
     
 0.697
rnz
Metallo-beta-lactamase; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family.
 
    0.619
hmaA
Archaeal histone.
 
   
 0.605
tbp-1
TATA-binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
  
   
 0.565
leuB
3-isopropylmalate dehydrogenase.
     
 0.548
leuB-2
3-isopropylmalate dehydrogenase.
     
 0.548
MA_1385
Aspartate aminotransferase.
 
   
 0.540
Your Current Organism:
Methanosarcina acetivorans
NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A
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