node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
frhG | hdrA | MA_0977 | MA_2868 | Coenzyme F420 hydrogenase, subunit gamma. | Heterodisulfide reductase, subunit A/methylviologen reducing hydrogenase, subunit delta; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB- CoM heterodisulfide. Th [...] | 0.885 |
frhG | hdrA-2 | MA_0977 | MA_3128 | Coenzyme F420 hydrogenase, subunit gamma. | Heterodisulfide reductase, subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Probably involved in methylotrophic methanogenesis but not in aceticlastic methanogenesis. | 0.894 |
frhG | hypA | MA_0977 | MA_1138 | Coenzyme F420 hydrogenase, subunit gamma. | Hydrogenase expression/formation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.582 |
frhG | hypC | MA_0977 | MA_1140 | Coenzyme F420 hydrogenase, subunit gamma. | Hydrogenase expression/formation protein. | 0.525 |
frhG | hypD | MA_0977 | MA_1139 | Coenzyme F420 hydrogenase, subunit gamma. | Hydrogenase expression/formation protein. | 0.592 |
frhG | vhtA | MA_0977 | MA_1142 | Coenzyme F420 hydrogenase, subunit gamma. | F420-nonreducing hydrogenase; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | 0.883 |
frhG | vhtD | MA_0977 | MA_1144 | Coenzyme F420 hydrogenase, subunit gamma. | F420-nonreducing hydrogenase II. | 0.604 |
hdrA | frhG | MA_2868 | MA_0977 | Heterodisulfide reductase, subunit A/methylviologen reducing hydrogenase, subunit delta; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB- CoM heterodisulfide. Th [...] | Coenzyme F420 hydrogenase, subunit gamma. | 0.885 |
hdrA | hdrA-2 | MA_2868 | MA_3128 | Heterodisulfide reductase, subunit A/methylviologen reducing hydrogenase, subunit delta; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB- CoM heterodisulfide. Th [...] | Heterodisulfide reductase, subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Probably involved in methylotrophic methanogenesis but not in aceticlastic methanogenesis. | 0.910 |
hdrA | vhtA | MA_2868 | MA_1142 | Heterodisulfide reductase, subunit A/methylviologen reducing hydrogenase, subunit delta; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB- CoM heterodisulfide. Th [...] | F420-nonreducing hydrogenase; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | 0.823 |
hdrA | vhtC | MA_2868 | MA_1143 | Heterodisulfide reductase, subunit A/methylviologen reducing hydrogenase, subunit delta; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB- CoM heterodisulfide. Th [...] | Cytochrome b. | 0.596 |
hdrA | vhtD | MA_2868 | MA_1144 | Heterodisulfide reductase, subunit A/methylviologen reducing hydrogenase, subunit delta; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB- CoM heterodisulfide. Th [...] | F420-nonreducing hydrogenase II. | 0.442 |
hdrA-2 | frhG | MA_3128 | MA_0977 | Heterodisulfide reductase, subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Probably involved in methylotrophic methanogenesis but not in aceticlastic methanogenesis. | Coenzyme F420 hydrogenase, subunit gamma. | 0.894 |
hdrA-2 | hdrA | MA_3128 | MA_2868 | Heterodisulfide reductase, subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Probably involved in methylotrophic methanogenesis but not in aceticlastic methanogenesis. | Heterodisulfide reductase, subunit A/methylviologen reducing hydrogenase, subunit delta; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB- CoM heterodisulfide. Th [...] | 0.910 |
hdrA-2 | vhtA | MA_3128 | MA_1142 | Heterodisulfide reductase, subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Probably involved in methylotrophic methanogenesis but not in aceticlastic methanogenesis. | F420-nonreducing hydrogenase; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | 0.822 |
hdrA-2 | vhtC | MA_3128 | MA_1143 | Heterodisulfide reductase, subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Probably involved in methylotrophic methanogenesis but not in aceticlastic methanogenesis. | Cytochrome b. | 0.596 |
hdrA-2 | vhtD | MA_3128 | MA_1144 | Heterodisulfide reductase, subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Probably involved in methylotrophic methanogenesis but not in aceticlastic methanogenesis. | F420-nonreducing hydrogenase II. | 0.429 |
hypA | frhG | MA_1138 | MA_0977 | Hydrogenase expression/formation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | Coenzyme F420 hydrogenase, subunit gamma. | 0.582 |
hypA | hypC | MA_1138 | MA_1140 | Hydrogenase expression/formation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | Hydrogenase expression/formation protein. | 0.984 |
hypA | hypD | MA_1138 | MA_1139 | Hydrogenase expression/formation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | Hydrogenase expression/formation protein. | 0.987 |