STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
vhtAF420-nonreducing hydrogenase; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (595 aa)    
Predicted Functional Partners:
vhtG
F420-nonreducing hydrogenase.
 
 
 0.995
vhtG-2
F420-nonreducing hydrogenase.
 
 
 0.981
vhtD
F420-nonreducing hydrogenase II.
 
 
 0.923
hypA
Hydrogenase expression/formation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.906
vhtC
Cytochrome b.
     
 0.889
frhG
Coenzyme F420 hydrogenase, subunit gamma.
 
 
 0.883
hypD
Hydrogenase expression/formation protein.
 
 
 0.864
hypC
Hydrogenase expression/formation protein.
 
 
 0.835
hdrA
Heterodisulfide reductase, subunit A/methylviologen reducing hydrogenase, subunit delta; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB- CoM heterodisulfide. Th [...]
  
 
 0.823
hdrA-2
Heterodisulfide reductase, subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Probably involved in methylotrophic methanogenesis but not in aceticlastic methanogenesis.
  
 
 0.822
Your Current Organism:
Methanosarcina acetivorans
NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A
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