istB-8 protein (Methanosarcina acetivorans) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

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co-expression

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gene co-occurrence

gene fusions

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[Homology]

Score

istB-8

IstB helper protein. (257 aa)

Predicted Functional Partners:

MA_2202

0.777

MA_2888

0.698

rpl40e

0.637

psmA

0.556

psmB

0.530

MA_0087

0.528

hsp70

0.528

MA_1736

0.518

MA_0088

0.503

hsp40

0.503

Your Current Organism:

Methanosarcina acetivorans

NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MA_0087	MA_0088	MA_0087	MA_0088	DnaK protein.	DnaJ protein.	0.995
MA_0087	MA_1736	MA_0087	MA_1736	DnaK protein.	Mov34 family protein.	0.762
MA_0087	MA_2888	MA_0087	MA_2888	DnaK protein.	Histone deacetylase.	0.770
MA_0087	hsp40	MA_0087	MA_1479	DnaK protein.	Heat shock protein 40; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, Dn [...]	0.993
MA_0087	hsp70	MA_0087	MA_1478	DnaK protein.	Heat shock protein 70; Acts as a chaperone.	0.902
MA_0087	istB-8	MA_0087	MA_2201	DnaK protein.	IstB helper protein.	0.528
MA_0087	psmA	MA_0087	MA_1779	DnaK protein.	Multicatalytic endopeptidase complex, subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.	0.528
MA_0087	psmB	MA_0087	MA_3873	DnaK protein.	Multicatalytic endopeptidase complex, subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.	0.528
MA_0087	rpl40e	MA_0087	MA_3970	DnaK protein.	Ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.	0.591
MA_0088	MA_0087	MA_0088	MA_0087	DnaJ protein.	DnaK protein.	0.995
MA_0088	MA_1736	MA_0088	MA_1736	DnaJ protein.	Mov34 family protein.	0.627
MA_0088	MA_2888	MA_0088	MA_2888	DnaJ protein.	Histone deacetylase.	0.783
MA_0088	hsp70	MA_0088	MA_1478	DnaJ protein.	Heat shock protein 70; Acts as a chaperone.	0.991
MA_0088	istB-8	MA_0088	MA_2201	DnaJ protein.	IstB helper protein.	0.503
MA_1736	MA_0087	MA_1736	MA_0087	Mov34 family protein.	DnaK protein.	0.762
MA_1736	MA_0088	MA_1736	MA_0088	Mov34 family protein.	DnaJ protein.	0.627
MA_1736	MA_2888	MA_1736	MA_2888	Mov34 family protein.	Histone deacetylase.	0.500
MA_1736	hsp40	MA_1736	MA_1479	Mov34 family protein.	Heat shock protein 40; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, Dn [...]	0.625
MA_1736	hsp70	MA_1736	MA_1478	Mov34 family protein.	Heat shock protein 70; Acts as a chaperone.	0.762
MA_1736	istB-8	MA_1736	MA_2201	Mov34 family protein.	IstB helper protein.	0.518