Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
porB-2Pyruvate synthase, beta subunit. (296 aa)    
Predicted Functional Partners:
porA
Pyruvate synthase, subunit alpha.
 0.999
porD
Pyruvate synthase, subunit delta.
 
 0.999
porG
Pyruvate synthase, subunit gamma.
 
 0.998
cooF
Carbon-monoxide dehydrogenase, Fe-S subunit.
  
 
 0.987
MA_3075
2-oxoacid ferredoxin oxidoreductase, subunit alpha.
  
 0.985
MA_2912
AMP-binding protein.
  
 
 0.929
cdhE
Carbon-monoxide dehydrogenase, subunit gamma; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.
  
 
 0.925
pycB
Pyruvate carboxylase subunit B.
  
 
 0.919
cdhD
Carbon-monoxide dehydrogenase, subunit delta; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex (By similarity).
  
 
  0.919
acdA
acetate-CoA ligase (ADP-forming), subunit alpha.
    
 0.919
Your Current Organism:
Methanosarcina acetivorans
NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A
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