Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (256 aa)    
Predicted Functional Partners:
MA_3731
Cytidylyltransferase.
 
  
 0.936
nadK
Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
  
 0.935
MA_1030
NAD(+) synthase (glutamine-hydrolyzing); Belongs to the NAD synthetase family.
  
  
 
0.912
MA_1439
NAD+ pyrophosphatase.
  
 
 0.912
MA_3715
NH(3)-dependent NAD(+) synthetase.
  
  
 
0.910
MA_0920
Conserved hypothetical protein.
       0.647
pncB
Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family.
 
  
 0.598
MA_3020
Conserved hypothetical protein.
       0.597
MA_0491
Bacterial extracellular solute-binding family 3 protein.
     
 0.551
MA_1736
Mov34 family protein.
  
   0.443
Your Current Organism:
Methanosarcina acetivorans
NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A
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