Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
psmBMulticatalytic endopeptidase complex, subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (210 aa)    
Predicted Functional Partners:
psmA
Multicatalytic endopeptidase complex, subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.974
pan
Proteasome-activating nucleotidase; Belongs to the AAA ATPase family.
 
 0.919
pan-2
Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...]
 
 0.919
MA_1736
Mov34 family protein.
   
 0.914
MA_3874
Cleavage and polyadenylation specificity factor.
 
   
 0.893
MA_4121
Predicted protein.
  
 0.884
MA_4682
Metal-dependent phosphohydrolase.
 
     0.852
tfe
Archaeal transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexe [...]
       0.820
rpl40e
Ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 0.814
rpl7ae
Ribosomal protein L7ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
 
 
 0.629
Your Current Organism:
Methanosarcina acetivorans
NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A
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