Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MA_4352Hypothetical protein (multi-domain). (703 aa)    
Predicted Functional Partners:
rps5
Ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy.
    
 0.564
pylC
Predicted protein; Likely catalyzes the ATP-dependent ligation between (2R,3R)- 3-methylornithine and L-lysine, leading to (3R)-3-methyl-D-ornithyl-N6- L-lysine. Is required for the biosynthesis of pyrrolysine. Belongs to the PylC family.
   
 
 0.554
bioB
Biotin synthase; Catalyzes the isomerization of L-lysine to (2R,3R)-3- methylornithine via a radical-based mechanism (Probable). Is required for the biosynthesis of pyrrolysine; Belongs to the radical SAM superfamily. PylB family.
  
  
 0.525
fpoB
F(420)H(2) dehydrogenase, subunit FpoB; Belongs to the complex I 20 kDa subunit family.
   
 0.519
pylD
Predicted protein; Likely catalyzes the NAD(P)-dependent oxidative deamination of (3R)-3-methyl-D-ornithyl-N6-L-lysine, resulting in the formation of pyrrolysine after spontaneous dehydration and cyclization of the intermediate. Is required for the biosynthesis of pyrrolysine.
      
 0.510
fpoD
F(420)H(2) dehydrogenase, subunit FpoD.
    
 0.505
MA_2309
Hypothetical protein (multi-domain).
   
 
 0.470
pylS
Predicted protein; Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
      
 0.462
rps9
Ribosomal protein S9p; Belongs to the universal ribosomal protein uS9 family.
    
 0.455
pepN
Membrane alanine aminopeptidase.
 
 
 
 0.406
Your Current Organism:
Methanosarcina acetivorans
NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A
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