| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| asn | purA | MA_1966 | MA_4118 | Asparagine synthase (glutamine-hydrolyzing). | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.927 |
| asn | purA1 | MA_1966 | MA_1919 | Asparagine synthase (glutamine-hydrolyzing). | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.927 |
| asn | pyrB | MA_1966 | MA_4502 | Asparagine synthase (glutamine-hydrolyzing). | Aspartate carbamoyltransferase, catalytic subunit. | 0.931 |
| asn | pyrI | MA_1966 | MA_4501 | Asparagine synthase (glutamine-hydrolyzing). | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. | 0.903 |
| carA | carB | MA_2144 | MA_2143 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), small subunit; Belongs to the CarA family. | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), large subunit. | 0.999 |
| carA | purA | MA_2144 | MA_4118 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), small subunit; Belongs to the CarA family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.448 |
| carA | purA1 | MA_2144 | MA_1919 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), small subunit; Belongs to the CarA family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.450 |
| carA | pyrB | MA_2144 | MA_4502 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), small subunit; Belongs to the CarA family. | Aspartate carbamoyltransferase, catalytic subunit. | 0.999 |
| carA | pyrC | MA_2144 | MA_0892 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), small subunit; Belongs to the CarA family. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.995 |
| carA | pyrD | MA_2144 | MA_0583 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), small subunit; Belongs to the CarA family. | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.960 |
| carA | pyrE-2 | MA_2144 | MA_3307 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), small subunit; Belongs to the CarA family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.951 |
| carA | pyrF | MA_2144 | MA_0969 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), small subunit; Belongs to the CarA family. | Orotidine-5-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.936 |
| carA | pyrI | MA_2144 | MA_4501 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), small subunit; Belongs to the CarA family. | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. | 0.966 |
| carB | carA | MA_2143 | MA_2144 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), large subunit. | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), small subunit; Belongs to the CarA family. | 0.999 |
| carB | purA | MA_2143 | MA_4118 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), large subunit. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.602 |
| carB | purA1 | MA_2143 | MA_1919 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), large subunit. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.599 |
| carB | pyrB | MA_2143 | MA_4502 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), large subunit. | Aspartate carbamoyltransferase, catalytic subunit. | 0.998 |
| carB | pyrC | MA_2143 | MA_0892 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), large subunit. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.985 |
| carB | pyrD | MA_2143 | MA_0583 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), large subunit. | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.895 |
| carB | pyrE-2 | MA_2143 | MA_3307 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing), large subunit. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.873 |