node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MA_3967 | MA_3998 | MA_3967 | MA_3998 | Methylcoenzyme M reductase system, component A2. | ABC transporter, ATP-binding protein. | 0.913 |
MA_3967 | MA_4547 | MA_3967 | MA_4547 | Methylcoenzyme M reductase system, component A2. | Methyl coenzyme M reductase, subunit gamma. | 0.965 |
MA_3967 | MA_4548 | MA_3967 | MA_4548 | Methylcoenzyme M reductase system, component A2. | Methyl coenzyme M reductase, subunit D. | 0.967 |
MA_3967 | MA_4549 | MA_3967 | MA_4549 | Methylcoenzyme M reductase system, component A2. | Methyl coenzyme M reductase, subunit C. | 0.969 |
MA_3967 | MA_4550 | MA_3967 | MA_4550 | Methylcoenzyme M reductase system, component A2. | Methyl coenzyme M reductase, subunit beta. | 0.962 |
MA_3967 | MA_4551 | MA_3967 | MA_4551 | Methylcoenzyme M reductase system, component A2. | Conserved hypothetical protein; Radical SAM methyltransferase that is responsible for the C(5)-methylation of 'Arg-285' of the methyl-coenzyme M reductase (MCR) subunit alpha McrA. This post-translational methylation, despite being not essential in vivo, plays a role for the stability and structural integrity of MCR. | 0.513 |
MA_3967 | hdrA | MA_3967 | MA_2868 | Methylcoenzyme M reductase system, component A2. | Heterodisulfide reductase, subunit A/methylviologen reducing hydrogenase, subunit delta; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB- CoM heterodisulfide. Th [...] | 0.718 |
MA_3967 | mcrA | MA_3967 | MA_4546 | Methylcoenzyme M reductase system, component A2. | Methyl coenzyme M reductase, subunit alpha; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. | 0.964 |
MA_3967 | mtrA | MA_3967 | MA_0272 | Methylcoenzyme M reductase system, component A2. | Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. | 0.820 |
MA_3967 | mtrH | MA_3967 | MA_0269 | Methylcoenzyme M reductase system, component A2. | Tetrahydromethanopterin S-methyltransferase, subunit H; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA. | 0.818 |
MA_3998 | MA_3967 | MA_3998 | MA_3967 | ABC transporter, ATP-binding protein. | Methylcoenzyme M reductase system, component A2. | 0.913 |
MA_3998 | MA_4547 | MA_3998 | MA_4547 | ABC transporter, ATP-binding protein. | Methyl coenzyme M reductase, subunit gamma. | 0.973 |
MA_3998 | MA_4548 | MA_3998 | MA_4548 | ABC transporter, ATP-binding protein. | Methyl coenzyme M reductase, subunit D. | 0.985 |
MA_3998 | MA_4549 | MA_3998 | MA_4549 | ABC transporter, ATP-binding protein. | Methyl coenzyme M reductase, subunit C. | 0.980 |
MA_3998 | MA_4550 | MA_3998 | MA_4550 | ABC transporter, ATP-binding protein. | Methyl coenzyme M reductase, subunit beta. | 0.974 |
MA_3998 | MA_4551 | MA_3998 | MA_4551 | ABC transporter, ATP-binding protein. | Conserved hypothetical protein; Radical SAM methyltransferase that is responsible for the C(5)-methylation of 'Arg-285' of the methyl-coenzyme M reductase (MCR) subunit alpha McrA. This post-translational methylation, despite being not essential in vivo, plays a role for the stability and structural integrity of MCR. | 0.537 |
MA_3998 | hdrA | MA_3998 | MA_2868 | ABC transporter, ATP-binding protein. | Heterodisulfide reductase, subunit A/methylviologen reducing hydrogenase, subunit delta; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB- CoM heterodisulfide. Th [...] | 0.669 |
MA_3998 | mcrA | MA_3998 | MA_4546 | ABC transporter, ATP-binding protein. | Methyl coenzyme M reductase, subunit alpha; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. | 0.987 |
MA_3998 | mtrA | MA_3998 | MA_0272 | ABC transporter, ATP-binding protein. | Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. | 0.815 |
MA_3998 | mtrH | MA_3998 | MA_0269 | ABC transporter, ATP-binding protein. | Tetrahydromethanopterin S-methyltransferase, subunit H; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA. | 0.749 |