Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mrpAMultiple resistance/pH regulation related protein A (Na+/H+ antiporter). (806 aa)    
Predicted Functional Partners:
mrpC
Multiple resistance/pH regulation related protein C (Na+/H+ antiporter).
 
 
 0.993
mrpE
Multiple resistance/pH regulation related protein E (Na+/H+ antiporter).
 
 
 0.992
mrpB
Multiple resistance/pH regulation related protein B (Na+/H+ antiporter).
 
 
 0.992
mrpG
Multiple resistance/pH regulation related protein G (Na+/H+ antiporter).
 
 
 0.991
mrpF
Multiple resistance/pH regulation related protein F (Na+/H+ antiporter).
 
 
 0.986
fpoI
F(420)H(2) dehydrogenase, subunit FpoI.
 
 
 0.980
mrpD
Multiple resistance/pH regulation related protein D (Na+/H+ antiporter).
 
 
0.978
fpoH
F(420)H(2) dehydrogenase, subunit FpoH; Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2):heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples th [...]
 
 
 0.976
fpoM
F(420)H(2) dehydrogenase, subunit FpoM.
 
 
0.974
fpoN
F(420)H(2) dehydrogenase, subunit FpoN.
 
 
0.974
Your Current Organism:
Methanosarcina acetivorans
NCBI taxonomy Id: 188937
Other names: M. acetivorans C2A, Methanosarcina acetivorans C2A, Methanosarcina acetivorans str. C2A
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