node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MA_0316 | MA_4584 | MA_0316 | MA_4584 | Phosphoribosylglycinamide formyltransferase. | Hypothetical protein (multi-domain). | 0.915 |
MA_0316 | folD | MA_0316 | MA_3519 | Phosphoribosylglycinamide formyltransferase. | Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.970 |
MA_0316 | glyA | MA_0316 | MA_3520 | Phosphoribosylglycinamide formyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.961 |
MA_0316 | purC | MA_0316 | MA_4063 | Phosphoribosylglycinamide formyltransferase. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.922 |
MA_0316 | purD | MA_0316 | MA_3309 | Phosphoribosylglycinamide formyltransferase. | Phosphoribosylamine-glycine ligase. | 0.999 |
MA_0316 | purH | MA_0316 | MA_4012 | Phosphoribosylglycinamide formyltransferase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.996 |
MA_0316 | purL | MA_0316 | MA_4055 | Phosphoribosylglycinamide formyltransferase. | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] | 0.984 |
MA_0316 | purN | MA_0316 | MA_3522 | Phosphoribosylglycinamide formyltransferase. | Phosphoribosylglycinamide formyltransferase. | 0.908 |
MA_0316 | purQ | MA_0316 | MA_1963 | Phosphoribosylglycinamide formyltransferase. | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] | 0.984 |
MA_0316 | purS | MA_0316 | MA_1964 | Phosphoribosylglycinamide formyltransferase. | Conserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] | 0.979 |
MA_4584 | MA_0316 | MA_4584 | MA_0316 | Hypothetical protein (multi-domain). | Phosphoribosylglycinamide formyltransferase. | 0.915 |
MA_4584 | folD | MA_4584 | MA_3519 | Hypothetical protein (multi-domain). | Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.959 |
MA_4584 | glyA | MA_4584 | MA_3520 | Hypothetical protein (multi-domain). | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.960 |
MA_4584 | purC | MA_4584 | MA_4063 | Hypothetical protein (multi-domain). | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.895 |
MA_4584 | purD | MA_4584 | MA_3309 | Hypothetical protein (multi-domain). | Phosphoribosylamine-glycine ligase. | 0.979 |
MA_4584 | purH | MA_4584 | MA_4012 | Hypothetical protein (multi-domain). | Phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.983 |
MA_4584 | purL | MA_4584 | MA_4055 | Hypothetical protein (multi-domain). | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] | 0.979 |
MA_4584 | purN | MA_4584 | MA_3522 | Hypothetical protein (multi-domain). | Phosphoribosylglycinamide formyltransferase. | 0.916 |
MA_4584 | purQ | MA_4584 | MA_1963 | Hypothetical protein (multi-domain). | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] | 0.979 |
MA_4584 | purS | MA_4584 | MA_1964 | Hypothetical protein (multi-domain). | Conserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] | 0.979 |