PROFUN_02510 protein (Planoprotostelium fungivorum)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Gene Fusion

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[Homology]

Score

PROFUN_02510

Uncharacterized protein. (802 aa)

Predicted Functional Partners:

PROFUN_13760

0.925

PROFUN_05870

0.900

PROFUN_06189

0.871

PROFUN_05468

0.869

PROFUN_04286

0.863

PROFUN_00391

0.833

PROFUN_15001

0.808

PROFUN_01055

0.808

PROFUN_06244

0.782

PROFUN_10098

0.782

Your Current Organism:

Planoprotostelium fungivorum

NCBI taxonomy Id: 1890364
Other names: P. fungivorum, Planoprotostelium fungivorum Hillmann, Ferling, Novohradska & Gloeckner 2017, Protostelium sp. Jena Gg-2016a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PROFUN_00391	PROFUN_01055	A0A2P6NY84	A0A2P6N4L6	Pantothenate synthetase.	CN hydrolase domain-containing protein.	0.852
PROFUN_00391	PROFUN_02510	A0A2P6NY84	A0A2P6MP71	Pantothenate synthetase.	Uncharacterized protein.	0.833
PROFUN_00391	PROFUN_05468	A0A2P6NY84	A0A2P6NQU6	Pantothenate synthetase.	Glutamate decarboxylase; Belongs to the group II decarboxylase family.	0.913
PROFUN_00391	PROFUN_06189	A0A2P6NY84	A0A2P6MYY2	Pantothenate synthetase.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.896
PROFUN_00391	PROFUN_06244	A0A2P6NY84	A0A2P6NE81	Pantothenate synthetase.	4-aminobutyrate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.846
PROFUN_00391	PROFUN_10098	A0A2P6NY84	A0A2P6NF08	Pantothenate synthetase.	L-lysine 6-transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.846
PROFUN_00391	PROFUN_13760	A0A2P6NY84	A0A2P6N334	Pantothenate synthetase.	Gamma-glutamyl phosphate reductase.	0.601
PROFUN_00391	PROFUN_15001	A0A2P6NY84	A0A2P6MY02	Pantothenate synthetase.	CN hydrolase domain-containing protein.	0.852
PROFUN_01055	PROFUN_00391	A0A2P6N4L6	A0A2P6NY84	CN hydrolase domain-containing protein.	Pantothenate synthetase.	0.852
PROFUN_01055	PROFUN_02510	A0A2P6N4L6	A0A2P6MP71	CN hydrolase domain-containing protein.	Uncharacterized protein.	0.808
PROFUN_01055	PROFUN_05468	A0A2P6N4L6	A0A2P6NQU6	CN hydrolase domain-containing protein.	Glutamate decarboxylase; Belongs to the group II decarboxylase family.	0.836
PROFUN_01055	PROFUN_05870	A0A2P6N4L6	A0A2P6NKN4	CN hydrolase domain-containing protein.	Malate synthase.	0.905
PROFUN_01055	PROFUN_06189	A0A2P6N4L6	A0A2P6MYY2	CN hydrolase domain-containing protein.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.885
PROFUN_01055	PROFUN_06244	A0A2P6N4L6	A0A2P6NE81	CN hydrolase domain-containing protein.	4-aminobutyrate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.823
PROFUN_01055	PROFUN_10098	A0A2P6N4L6	A0A2P6NF08	CN hydrolase domain-containing protein.	L-lysine 6-transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.823
PROFUN_02510	PROFUN_00391	A0A2P6MP71	A0A2P6NY84	Uncharacterized protein.	Pantothenate synthetase.	0.833
PROFUN_02510	PROFUN_01055	A0A2P6MP71	A0A2P6N4L6	Uncharacterized protein.	CN hydrolase domain-containing protein.	0.808
PROFUN_02510	PROFUN_04286	A0A2P6MP71	A0A2P6NV17	Uncharacterized protein.	Methylmalonate-semialdehyde dehydrogenase.	0.863
PROFUN_02510	PROFUN_05468	A0A2P6MP71	A0A2P6NQU6	Uncharacterized protein.	Glutamate decarboxylase; Belongs to the group II decarboxylase family.	0.869
PROFUN_02510	PROFUN_05870	A0A2P6MP71	A0A2P6NKN4	Uncharacterized protein.	Malate synthase.	0.900

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.859

expected number of edges:

11

PPI enrichment p-value:

9.79e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016575

Histone deacetylation

8 of 16

2.86

8.97

4.64e-18

GO:0000122

Negative regulation of transcription by RNA polymerase II

4 of 52

2.04

2.52

5.97e-06

GO:0006325

Chromatin organization

6 of 217

1.6

2.31

5.17e-07

GO:0006355

Regulation of transcription, DNA-templated

10 of 711

1.31

2.1

2.39e-10

GO:0061188

Negative regulation of ribosomal DNA heterochromatin assembly

2 of 2

3.16

2.01

0.00023

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035064

Methylated histone binding

3 of 12

2.56

2.01

0.00019

GO:0003714

Transcription corepressor activity

3 of 21

2.31

1.88

0.00028

GO:0004407

Histone deacetylase activity

2 of 8

2.56

1.2

0.0063

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070822

Sin3-type complex

6 of 12

2.86

6.59

3.35e-13

GO:0033698

Rpd3L complex

4 of 6

2.98

4.41

7.53e-09

GO:0005654

Nucleoplasm

7 of 239

1.62

2.73

1.24e-08

GO:0032221

Rpd3S/Clr6-CII complex

2 of 3

2.98

1.98

0.00026

GO:0035267

NuA4 histone acetyltransferase complex

2 of 16

2.25

1.38

0.0026

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1510

Histone deacetylation, and Rpd3L-Expanded complex

10 of 12

3.08

13.17

6.06e-26

CL:1512

Histone deacetylation

5 of 6

3.08

5.87

1.48e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04139

Mitophagy - yeast

3 of 56

1.89

1.45

0.0012

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3214815

HDACs deacetylate histones

3 of 10

2.63

2.25

6.82e-05

MAP-9707564

Cytoprotection by HMOX1

3 of 28

2.19

1.71

0.00053

MAP-4839726

Chromatin organization

4 of 124

1.67

1.48

0.00053

MAP-3247509

Chromatin modifying enzymes

4 of 124

1.67

1.48

0.00053

MAP-212436

Generic Transcription Pathway

5 of 350

1.31

1.2

0.00053

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070822

Sin3-type complex

11 of 19

2.92

14.01

1.42e-28

GOCC:0033698

Rpd3L complex

6 of 9

2.98

7.36

1.53e-14

GOCC:0070210

Rpd3L-Expanded complex

3 of 6

2.86

3.21

1.24e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0539

Nucleus

4 of 349

1.22

0.73

0.0173

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02671

Paired amphipathic helix repeat

2 of 2

3.16

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039774

Transcriptional regulatory protein Sin3-like

2 of 2

3.16

1.16

0.0080

IPR036600

Paired amphipathic helix superfamily

2 of 2

3.16

1.16

0.0080

IPR003822

Paired amphipathic helix

2 of 2

3.16

1.16

0.0080

IPR019787

Zinc finger, PHD-finger

2 of 15

2.28

0.73

0.0453

IPR019786

Zinc finger, PHD-type, conserved site

2 of 16

2.25

0.73

0.0453

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00249

PHD zinc finger

2 of 23

2.1

0.73

0.0433

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