PROFUN_03612 protein (Planoprotostelium fungivorum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PROFUN_03612

Uncharacterized protein. (72 aa)

Predicted Functional Partners:

PROFUN_02560

0.999

PROFUN_11995

0.999

PROFUN_12015

0.999

PROFUN_07386

0.999

PROFUN_10683

0.999

PROFUN_08784

0.999

PROFUN_15125

0.999

PROFUN_00463

0.999

PROFUN_00587

0.999

PROFUN_00584

0.999

Your Current Organism:

Planoprotostelium fungivorum

NCBI taxonomy Id: 1890364
Other names: P. fungivorum, Planoprotostelium fungivorum Hillmann, Ferling, Novohradska & Gloeckner 2017, Protostelium sp. Jena Gg-2016a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PROFUN_00463	PROFUN_00584	A0A2P6N0X4	A0A2P6N1B3	Uncharacterized protein.	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	0.999
PROFUN_00463	PROFUN_00587	A0A2P6N0X4	A0A2P6N179	Uncharacterized protein.	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.999
PROFUN_00463	PROFUN_02560	A0A2P6N0X4	A0A2P6MPB7	Uncharacterized protein.	Putative 60S ribosomal protein L23.	0.999
PROFUN_00463	PROFUN_03612	A0A2P6N0X4	A0A2P6MSL1	Uncharacterized protein.	Uncharacterized protein.	0.999
PROFUN_00463	PROFUN_07386	A0A2P6N0X4	A0A2P6MTG1	Uncharacterized protein.	Ribosomal_L7Ae domain-containing protein.	0.999
PROFUN_00463	PROFUN_08784	A0A2P6N0X4	A0A2P6MVQ0	Uncharacterized protein.	Uncharacterized protein.	0.999
PROFUN_00463	PROFUN_10683	A0A2P6N0X4	A0A2P6MUW7	Uncharacterized protein.	40S ribosomal protein S4; Belongs to the eukaryotic ribosomal protein eS4 family.	0.999
PROFUN_00463	PROFUN_11995	A0A2P6N0X4	A0A2P6MRA8	Uncharacterized protein.	KH type-2 domain-containing protein.	0.999
PROFUN_00463	PROFUN_12015	A0A2P6N0X4	A0A2P6MRE9	Uncharacterized protein.	Uncharacterized protein.	0.999
PROFUN_00463	PROFUN_15125	A0A2P6N0X4	A0A2P6MZU8	Uncharacterized protein.	Ribosomal_L18e/L15P domain-containing protein.	0.999
PROFUN_00584	PROFUN_00463	A0A2P6N1B3	A0A2P6N0X4	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	Uncharacterized protein.	0.999
PROFUN_00584	PROFUN_00587	A0A2P6N1B3	A0A2P6N179	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.999
PROFUN_00584	PROFUN_02560	A0A2P6N1B3	A0A2P6MPB7	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	Putative 60S ribosomal protein L23.	0.999
PROFUN_00584	PROFUN_03612	A0A2P6N1B3	A0A2P6MSL1	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	Uncharacterized protein.	0.999
PROFUN_00584	PROFUN_07386	A0A2P6N1B3	A0A2P6MTG1	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	Ribosomal_L7Ae domain-containing protein.	0.999
PROFUN_00584	PROFUN_08784	A0A2P6N1B3	A0A2P6MVQ0	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	Uncharacterized protein.	0.999
PROFUN_00584	PROFUN_10683	A0A2P6N1B3	A0A2P6MUW7	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	40S ribosomal protein S4; Belongs to the eukaryotic ribosomal protein eS4 family.	0.999
PROFUN_00584	PROFUN_11995	A0A2P6N1B3	A0A2P6MRA8	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	KH type-2 domain-containing protein.	0.999
PROFUN_00584	PROFUN_12015	A0A2P6N1B3	A0A2P6MRE9	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	Uncharacterized protein.	0.999
PROFUN_00584	PROFUN_15125	A0A2P6N1B3	A0A2P6MZU8	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	Ribosomal_L18e/L15P domain-containing protein.	0.999

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

17

PPI enrichment p-value:

3.4e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098609

Cell-cell adhesion

5 of 435

1.54

1.27

0.0013

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045294

Alpha-catenin binding

2 of 10

2.78

0.97

0.0174

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0014704

Intercalated disc

2 of 11

2.74

1.28

0.0048

GO:0005911

Cell-cell junction

4 of 317

1.58

1.15

0.0032

GO:0016342

Catenin complex

2 of 30

2.31

0.98

0.0154

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:37965

Cadherin-like superfamily, and Plakophilin/Delta catenin

5 of 97

2.2

3.1

5.32e-07

CL:38071

Mixed, incl. Limb expression 1, and Retina layer formation

3 of 11

2.92

2.95

3.94e-06

CL:6049

RHOU GTPase cycle, and Unconventional class IX myosin

3 of 14

2.81

2.83

6.30e-06

CL:37972

Cadherin-like superfamily, and Plakophilin/Delta catenin

4 of 85

2.16

2.61

5.75e-06

CL:38074

Limb expression 1, and Retina layer formation

2 of 5

3.09

1.87

0.00042

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04392

Hippo signaling pathway - multiple species

3 of 102

1.95

1.51

0.00098

map04520

Adherens junction

3 of 115

1.9

1.49

0.00098

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9013026

RHOB GTPase cycle

3 of 71

2.11

1.35

0.0027

MAP-8980692

RHOA GTPase cycle

3 of 178

1.71

0.86

0.0199

MAP-5218920

VEGFR2 mediated vascular permeability

2 of 35

2.24

0.79

0.0347

MAP-418990

Adherens junctions interactions

2 of 40

2.18

0.79

0.0347

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005911

Cell-cell junction

4 of 224

1.74

1.42

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0518

Myosin

2 of 56

2.04

0.7

0.0499

KW-0106

Calcium

3 of 368

1.39

0.62

0.0499

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046987

Unconventional class IX myosin

3 of 4

3.36

2.87

6.62e-06

IPR036023

Class IX myosin, motor domain

2 of 2

3.48

1.49

0.0021

IPR013284

Beta-catenin

2 of 3

3.31

1.47

0.0023

IPR020894

Cadherin conserved site

3 of 107

1.93

1.04

0.0100

IPR015919

Cadherin-like superfamily

3 of 122

1.87

0.99

0.0118

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00112

Cadherin repeats.

3 of 118

1.89

1.14

0.0057

SM00314

Ras association (RalGDS/AF-6) domain

2 of 30

2.31

0.94

0.0187

SM00185

Armadillo/beta-catenin-like repeats

2 of 32

2.28

0.94

0.0187

SM00242

Myosin. Large ATPases.

2 of 38

2.2

0.93

0.0187

SM00282

Laminin G domain

2 of 50

2.09

0.91

0.0199

(more ...)

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