PROFUN_06667 protein (Planoprotostelium fungivorum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PROFUN_06667

Putative TBP associated factor (Mot1). (1627 aa)

Predicted Functional Partners:

PROFUN_12449

0.896

PROFUN_08573

0.811

PROFUN_10137

0.811

PROFUN_09465

0.811

PROFUN_08379

0.811

PROFUN_15595

0.650

PROFUN_14125

0.646

PROFUN_12847

0.618

PROFUN_03974

0.615

PROFUN_10412

0.573

Your Current Organism:

Planoprotostelium fungivorum

NCBI taxonomy Id: 1890364
Other names: P. fungivorum, Planoprotostelium fungivorum Hillmann, Ferling, Novohradska & Gloeckner 2017, Protostelium sp. Jena Gg-2016a

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PROFUN_03974	PROFUN_06667	A0A2P6NW07	A0A2P6MSY7	Essential subunit of the histone deacetylase Rpd3S complex.	Putative TBP associated factor (Mot1).	0.615
PROFUN_06667	PROFUN_03974	A0A2P6MSY7	A0A2P6NW07	Putative TBP associated factor (Mot1).	Essential subunit of the histone deacetylase Rpd3S complex.	0.615
PROFUN_06667	PROFUN_08379	A0A2P6MSY7	A0A2P6NJR9	Putative TBP associated factor (Mot1).	TATA box-binding protein-like protein 2-like.	0.811
PROFUN_06667	PROFUN_08573	A0A2P6MSY7	A0A2P6N1S4	Putative TBP associated factor (Mot1).	TATA box-binding protein-like protein 2-like.	0.811
PROFUN_06667	PROFUN_09465	A0A2P6MSY7	A0A2P6NH21	Putative TBP associated factor (Mot1).	RTR1-type domain-containing protein.	0.811
PROFUN_06667	PROFUN_10137	A0A2P6MSY7	A0A2P6NEQ7	Putative TBP associated factor (Mot1).	Uncharacterized protein.	0.811
PROFUN_06667	PROFUN_10412	A0A2P6MSY7	A0A2P6NE08	Putative TBP associated factor (Mot1).	DNA-binding protein RFX2 isoform 1.	0.573
PROFUN_06667	PROFUN_12449	A0A2P6MSY7	A0A2P6N7C0	Putative TBP associated factor (Mot1).	Uncharacterized protein.	0.896
PROFUN_06667	PROFUN_12847	A0A2P6MSY7	A0A2P6N6J7	Putative TBP associated factor (Mot1).	TFIID_20kDa domain-containing protein.	0.618
PROFUN_06667	PROFUN_14125	A0A2P6MSY7	A0A2P6N1C3	Putative TBP associated factor (Mot1).	Transcription initiation factor TFIID subunit 2.	0.646
PROFUN_06667	PROFUN_15595	A0A2P6MSY7	A0A2P6MV57	Putative TBP associated factor (Mot1).	Chromo domain-containing protein.	0.650
PROFUN_08379	PROFUN_06667	A0A2P6NJR9	A0A2P6MSY7	TATA box-binding protein-like protein 2-like.	Putative TBP associated factor (Mot1).	0.811
PROFUN_08379	PROFUN_12449	A0A2P6NJR9	A0A2P6N7C0	TATA box-binding protein-like protein 2-like.	Uncharacterized protein.	0.777
PROFUN_08379	PROFUN_12847	A0A2P6NJR9	A0A2P6N6J7	TATA box-binding protein-like protein 2-like.	TFIID_20kDa domain-containing protein.	0.915
PROFUN_08379	PROFUN_14125	A0A2P6NJR9	A0A2P6N1C3	TATA box-binding protein-like protein 2-like.	Transcription initiation factor TFIID subunit 2.	0.915
PROFUN_08573	PROFUN_06667	A0A2P6N1S4	A0A2P6MSY7	TATA box-binding protein-like protein 2-like.	Putative TBP associated factor (Mot1).	0.811
PROFUN_08573	PROFUN_12449	A0A2P6N1S4	A0A2P6N7C0	TATA box-binding protein-like protein 2-like.	Uncharacterized protein.	0.777
PROFUN_08573	PROFUN_12847	A0A2P6N1S4	A0A2P6N6J7	TATA box-binding protein-like protein 2-like.	TFIID_20kDa domain-containing protein.	0.915
PROFUN_08573	PROFUN_14125	A0A2P6N1S4	A0A2P6N1C3	TATA box-binding protein-like protein 2-like.	Transcription initiation factor TFIID subunit 2.	0.915
PROFUN_09465	PROFUN_06667	A0A2P6NH21	A0A2P6MSY7	RTR1-type domain-containing protein.	Putative TBP associated factor (Mot1).	0.811

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.859

expected number of edges:

11

PPI enrichment p-value:

9.79e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016575

Histone deacetylation

8 of 16

2.86

8.97

4.64e-18

GO:0000122

Negative regulation of transcription by RNA polymerase II

4 of 52

2.04

2.52

5.97e-06

GO:0006325

Chromatin organization

6 of 217

1.6

2.31

5.17e-07

GO:0006355

Regulation of transcription, DNA-templated

10 of 711

1.31

2.1

2.39e-10

GO:0061188

Negative regulation of ribosomal DNA heterochromatin assembly

2 of 2

3.16

2.01

0.00023

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035064

Methylated histone binding

3 of 12

2.56

2.01

0.00019

GO:0003714

Transcription corepressor activity

3 of 21

2.31

1.88

0.00028

GO:0004407

Histone deacetylase activity

2 of 8

2.56

1.2

0.0063

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070822

Sin3-type complex

6 of 12

2.86

6.59

3.35e-13

GO:0033698

Rpd3L complex

4 of 6

2.98

4.41

7.53e-09

GO:0005654

Nucleoplasm

7 of 239

1.62

2.73

1.24e-08

GO:0032221

Rpd3S/Clr6-CII complex

2 of 3

2.98

1.98

0.00026

GO:0035267

NuA4 histone acetyltransferase complex

2 of 16

2.25

1.38

0.0026

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1510

Histone deacetylation, and Rpd3L-Expanded complex

10 of 12

3.08

13.17

6.06e-26

CL:1512

Histone deacetylation

5 of 6

3.08

5.87

1.48e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04139

Mitophagy - yeast

3 of 56

1.89

1.45

0.0012

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3214815

HDACs deacetylate histones

3 of 10

2.63

2.25

6.82e-05

MAP-9707564

Cytoprotection by HMOX1

3 of 28

2.19

1.71

0.00053

MAP-4839726

Chromatin organization

4 of 124

1.67

1.48

0.00053

MAP-3247509

Chromatin modifying enzymes

4 of 124

1.67

1.48

0.00053

MAP-212436

Generic Transcription Pathway

5 of 350

1.31

1.2

0.00053

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070822

Sin3-type complex

11 of 19

2.92

14.01

1.42e-28

GOCC:0033698

Rpd3L complex

6 of 9

2.98

7.36

1.53e-14

GOCC:0070210

Rpd3L-Expanded complex

3 of 6

2.86

3.21

1.24e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0539

Nucleus

4 of 349

1.22

0.73

0.0173

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02671

Paired amphipathic helix repeat

2 of 2

3.16

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039774

Transcriptional regulatory protein Sin3-like

2 of 2

3.16

1.16

0.0080

IPR036600

Paired amphipathic helix superfamily

2 of 2

3.16

1.16

0.0080

IPR003822

Paired amphipathic helix

2 of 2

3.16

1.16

0.0080

IPR019787

Zinc finger, PHD-finger

2 of 15

2.28

0.73

0.0453

IPR019786

Zinc finger, PHD-type, conserved site

2 of 16

2.25

0.73

0.0453

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00249

PHD zinc finger

2 of 23

2.1

0.73

0.0433

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About