PROFUN_03920 protein (Planoprotostelium fungivorum)

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

PROFUN_03920

Signal transducer and activator of transcription. (623 aa)

Predicted Functional Partners:

PROFUN_02472

0.747

PROFUN_15507

0.747

PROFUN_11237

0.665

PROFUN_07232

0.665

PROFUN_15123

0.653

PROFUN_10326

0.653

PROFUN_05808

0.653

PROFUN_07882

0.649

PROFUN_09281

0.631

PROFUN_06600

0.611

Your Current Organism:

Planoprotostelium fungivorum

NCBI taxonomy Id: 1890364
Other names: P. fungivorum, Planoprotostelium fungivorum Hillmann, Ferling, Novohradska & Gloeckner 2017, Protostelium sp. Jena Gg-2016a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PROFUN_02472	PROFUN_03920	A0A2P6MP29	A0A2P6MTS6	Receptor-type tyrosine-protein phosphatase zeta.	Signal transducer and activator of transcription.	0.747
PROFUN_02472	PROFUN_07232	A0A2P6MP29	A0A2P6NMB7	Receptor-type tyrosine-protein phosphatase zeta.	Epidermal growth factor receptor-like; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.583
PROFUN_02472	PROFUN_11237	A0A2P6MP29	A0A2P6NA52	Receptor-type tyrosine-protein phosphatase zeta.	Tyrosine-protein kinase FRK-like.	0.583
PROFUN_03920	PROFUN_02472	A0A2P6MTS6	A0A2P6MP29	Signal transducer and activator of transcription.	Receptor-type tyrosine-protein phosphatase zeta.	0.747
PROFUN_03920	PROFUN_05808	A0A2P6MTS6	A0A2P6NQ07	Signal transducer and activator of transcription.	E3 SUMO-protein ligase PIAS4 isoform 1.	0.653
PROFUN_03920	PROFUN_06600	A0A2P6MTS6	A0A2P6MRY9	Signal transducer and activator of transcription.	BZIP domain-containing protein.	0.611
PROFUN_03920	PROFUN_07232	A0A2P6MTS6	A0A2P6NMB7	Signal transducer and activator of transcription.	Epidermal growth factor receptor-like; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.665
PROFUN_03920	PROFUN_07882	A0A2P6MTS6	A0A2P6NL47	Signal transducer and activator of transcription.	Ephrin type-A receptor 10-like.	0.649
PROFUN_03920	PROFUN_09281	A0A2P6MTS6	A0A2P6NKZ4	Signal transducer and activator of transcription.	Uncharacterized protein.	0.631
PROFUN_03920	PROFUN_10326	A0A2P6MTS6	A0A2P6NDT2	Signal transducer and activator of transcription.	Uncharacterized protein.	0.653
PROFUN_03920	PROFUN_11237	A0A2P6MTS6	A0A2P6NA52	Signal transducer and activator of transcription.	Tyrosine-protein kinase FRK-like.	0.665
PROFUN_03920	PROFUN_15123	A0A2P6MTS6	A0A2P6MZT5	Signal transducer and activator of transcription.	Uncharacterized protein.	0.653
PROFUN_03920	PROFUN_15507	A0A2P6MTS6	A0A2P6MSQ5	Signal transducer and activator of transcription.	Receptor-type tyrosine-protein phosphatase zeta isoform 2.	0.747
PROFUN_05808	PROFUN_03920	A0A2P6NQ07	A0A2P6MTS6	E3 SUMO-protein ligase PIAS4 isoform 1.	Signal transducer and activator of transcription.	0.653
PROFUN_05808	PROFUN_09281	A0A2P6NQ07	A0A2P6NKZ4	E3 SUMO-protein ligase PIAS4 isoform 1.	Uncharacterized protein.	0.499
PROFUN_06600	PROFUN_03920	A0A2P6MRY9	A0A2P6MTS6	BZIP domain-containing protein.	Signal transducer and activator of transcription.	0.611
PROFUN_06600	PROFUN_09281	A0A2P6MRY9	A0A2P6NKZ4	BZIP domain-containing protein.	Uncharacterized protein.	0.706
PROFUN_07232	PROFUN_02472	A0A2P6NMB7	A0A2P6MP29	Epidermal growth factor receptor-like; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Receptor-type tyrosine-protein phosphatase zeta.	0.583
PROFUN_07232	PROFUN_03920	A0A2P6NMB7	A0A2P6MTS6	Epidermal growth factor receptor-like; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Signal transducer and activator of transcription.	0.665
PROFUN_07232	PROFUN_15507	A0A2P6NMB7	A0A2P6MSQ5	Epidermal growth factor receptor-like; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Receptor-type tyrosine-protein phosphatase zeta isoform 2.	0.583

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Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.915

expected number of edges:

12

PPI enrichment p-value:

5.55e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071555

Cell wall organization

4 of 50

1.38

0.77

0.0205

GO:0006508

Proteolysis

4 of 72

1.23

0.68

0.0253

GO:0000270

Peptidoglycan metabolic process

3 of 34

1.43

0.65

0.0430

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008658

Penicillin binding

5 of 7

2.34

3.61

6.60e-08

GO:0009002

Serine-type D-Ala-D-Ala carboxypeptidase activity

3 of 4

2.36

2.15

8.34e-05

GO:0008955

Peptidoglycan glycosyltransferase activity

2 of 2

2.48

1.37

0.0030

GO:0008233

Peptidase activity

4 of 90

1.13

0.8

0.0066

GO:0140096

Catalytic activity, acting on a protein

5 of 175

0.94

0.67

0.0064

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2306

Peptidoglycan biosynthesis

8 of 22

2.04

5.0

6.11e-13

CL:2330

Penicillin-binding protein, transpeptidase, and Carboxypeptidase

6 of 8

2.36

4.87

1.06e-10

CL:2303

Mixed, incl. Cell division, and Beta-lactamase/transpeptidase-like

10 of 54

1.75

4.23

2.56e-14

CL:2382

Mixed, incl. Ami_3, and PGBD superfamily

2 of 5

2.08

0.92

0.0191

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00550

Peptidoglycan biosynthesis

9 of 28

1.99

5.38

5.41e-15

map01502

Vancomycin resistance

2 of 13

1.67

0.71

0.0404

map01501

beta-Lactam resistance

3 of 54

1.23

0.61

0.0404

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0121

Carboxypeptidase

2 of 3

2.31

0.93

0.0191

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00905

Penicillin binding protein transpeptidase domain

5 of 5

2.48

4.0

1.71e-08

PF03717

Penicillin-binding Protein dimerisation domain

3 of 3

2.48

2.06

0.00014

PF00912

Transglycosylase

2 of 2

2.48

1.09

0.0101

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001460

Penicillin-binding protein, transpeptidase

5 of 5

2.48

3.95

2.22e-08

IPR012338

Beta-lactamase/transpeptidase-like

6 of 12

2.18

3.9

5.83e-09

IPR036138

Penicillin-binding protein, dimerisation domain superfamily

3 of 3

2.48

1.94

0.00024

IPR005311

Penicillin-binding protein, dimerisation domain

3 of 3

2.48

1.94

0.00024

IPR036950

Penicillin binding protein transglycosylase domain

2 of 2

2.48

0.99

0.0157

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00740

PASTA

2 of 2

2.48

1.19

0.0067

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