PROFUN_12631 protein (Planoprotostelium fungivorum)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

PROFUN_12631

Glucose-6-phosphate isomerase; Belongs to the GPI family. (565 aa)

Predicted Functional Partners:

PROFUN_04068

0.993

PROFUN_04292

0.992

PROFUN_02298

0.989

PROFUN_06055

0.987

PROFUN_02413

0.987

PROFUN_05833

0.984

PROFUN_03866

0.981

PROFUN_04268

0.978

PROFUN_04444

0.978

PROFUN_06642

0.974

Your Current Organism:

Planoprotostelium fungivorum

NCBI taxonomy Id: 1890364
Other names: P. fungivorum, Planoprotostelium fungivorum Hillmann, Ferling, Novohradska & Gloeckner 2017, Protostelium sp. Jena Gg-2016a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PROFUN_02298	PROFUN_02413	A0A2P6NYJ3	A0A2P6NUS1	Alpha-enolase.	Triosephosphate isomerase 1.	0.941
PROFUN_02298	PROFUN_03866	A0A2P6NYJ3	A0A2P6NIE8	Alpha-enolase.	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.	0.952
PROFUN_02298	PROFUN_04068	A0A2P6NYJ3	A0A2P6NJF7	Alpha-enolase.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	0.933
PROFUN_02298	PROFUN_04268	A0A2P6NYJ3	A0A2P6NUZ6	Alpha-enolase.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.977
PROFUN_02298	PROFUN_04292	A0A2P6NYJ3	A0A2P6NVD7	Alpha-enolase.	Phosphoglucomutase, chloroplastic-like.	0.765
PROFUN_02298	PROFUN_04444	A0A2P6NYJ3	A0A2P6NVQ8	Alpha-enolase.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.977
PROFUN_02298	PROFUN_05833	A0A2P6NYJ3	A0A2P6NKM1	Alpha-enolase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.922
PROFUN_02298	PROFUN_06055	A0A2P6NYJ3	A0A2P6NPQ3	Alpha-enolase.	Triosephosphate isomerase.	0.941
PROFUN_02298	PROFUN_06642	A0A2P6NYJ3	A0A2P6MSU4	Alpha-enolase.	Uncharacterized protein.	0.943
PROFUN_02298	PROFUN_12631	A0A2P6NYJ3	A0A2P6N749	Alpha-enolase.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.989
PROFUN_02413	PROFUN_02298	A0A2P6NUS1	A0A2P6NYJ3	Triosephosphate isomerase 1.	Alpha-enolase.	0.941
PROFUN_02413	PROFUN_03866	A0A2P6NUS1	A0A2P6NIE8	Triosephosphate isomerase 1.	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.	0.957
PROFUN_02413	PROFUN_04068	A0A2P6NUS1	A0A2P6NJF7	Triosephosphate isomerase 1.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	0.929
PROFUN_02413	PROFUN_04268	A0A2P6NUS1	A0A2P6NUZ6	Triosephosphate isomerase 1.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.731
PROFUN_02413	PROFUN_04292	A0A2P6NUS1	A0A2P6NVD7	Triosephosphate isomerase 1.	Phosphoglucomutase, chloroplastic-like.	0.716
PROFUN_02413	PROFUN_04444	A0A2P6NUS1	A0A2P6NVQ8	Triosephosphate isomerase 1.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.731
PROFUN_02413	PROFUN_05833	A0A2P6NUS1	A0A2P6NKM1	Triosephosphate isomerase 1.	Glyceraldehyde-3-phosphate dehydrogenase.	0.983
PROFUN_02413	PROFUN_06642	A0A2P6NUS1	A0A2P6MSU4	Triosephosphate isomerase 1.	Uncharacterized protein.	0.950
PROFUN_02413	PROFUN_12631	A0A2P6NUS1	A0A2P6N749	Triosephosphate isomerase 1.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.987
PROFUN_03866	PROFUN_02298	A0A2P6NIE8	A0A2P6NYJ3	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.	Alpha-enolase.	0.952

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.863

expected number of edges:

10

PPI enrichment p-value:

0.0387

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

5 of 136

1.71

1.79

9.30e-05

GO:0032787

Monocarboxylic acid metabolic process

6 of 316

1.43

1.51

9.30e-05

GO:0006637

acyl-CoA metabolic process

3 of 50

1.93

1.27

0.0032

GO:0000038

Very long-chain fatty acid metabolic process

2 of 11

2.41

1.2

0.0062

GO:0009150

Purine ribonucleotide metabolic process

4 of 216

1.42

1.04

0.0036

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016790

Thiolester hydrolase activity

5 of 34

2.32

3.61

6.27e-08

GO:0008474

Palmitoyl-(protein) hydrolase activity

3 of 7

2.78

2.48

2.83e-05

GO:0047617

acyl-CoA hydrolase activity

2 of 9

2.5

1.12

0.0090

GO:0016788

Hydrolase activity, acting on ester bonds

6 of 576

1.17

1.06

0.00048

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18735

Mixed, incl. Thiolester hydrolase activity, and Thioesterase superfamily

6 of 30

2.45

4.98

1.11e-10

CL:18753

acyl-CoA hydrolase activity, and Palmitoyl hydrolase activity

3 of 6

2.85

2.5

2.67e-05

CL:18772

Mixed, incl. Phospholipase/carboxylesterase/thioesterase, and 1-acylglycerophosphoserine O-acyltransferase activity

3 of 7

2.78

2.49

2.67e-05

CL:17449

Protein import into peroxisome matrix, docking, and Pex, N-terminal

2 of 17

2.22

0.85

0.0267

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01040

Biosynthesis of unsaturated fatty acids

4 of 67

1.93

2.22

1.93e-05

map01212

Fatty acid metabolism

3 of 103

1.61

1.14

0.0037

map00680

Methane metabolism

2 of 34

1.92

1.01

0.0110

map00030

Pentose phosphate pathway

2 of 46

1.79

0.96

0.0126

map00564

Glycerophospholipid metabolism

3 of 173

1.39

0.87

0.0110

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2046106

Alpha-linolenic acid (ALA) metabolism

4 of 25

2.35

2.85

3.07e-06

MAP-2046104

Alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

4 of 25

2.35

2.85

3.07e-06

MAP-389887

Beta-oxidation of pristanoyl-CoA

4 of 28

2.3

2.82

3.07e-06

MAP-193368

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

4 of 41

2.14

2.64

4.79e-06

MAP-390918

Peroxisomal lipid metabolism

4 of 48

2.07

2.52

6.95e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

4 of 187

1.48

0.97

0.0072

GOCC:0005782

Peroxisomal matrix

2 of 20

2.15

0.78

0.0366

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02551

Acyl-CoA thioesterase

2 of 2

3.15

1.31

0.0044

PF03959

Serine hydrolase (FSH1)

2 of 7

2.61

1.04

0.0130

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042171

Acyl-CoA thioesterase, double hotdog domain

2 of 2

3.15

1.06

0.0126

IPR003703

Acyl-CoA thioesterase

2 of 2

3.15

1.06

0.0126

IPR003140

Phospholipase/carboxylesterase/thioesterase

2 of 2

3.15

1.06

0.0126

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