PROFUN_12544 protein (Planoprotostelium fungivorum)

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Known Interactions

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Predicted Interactions

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PROFUN_12544

PPM-type phosphatase domain-containing protein; Belongs to the PP2C family. (1691 aa)

Predicted Functional Partners:

PROFUN_11317

0.825

PROFUN_02072

0.825

PROFUN_03347

0.749

PROFUN_06527

0.729

PROFUN_06210

0.721

PROFUN_12924

0.721

PROFUN_06249

0.717

PROFUN_14061

0.715

PROFUN_13787

0.709

PROFUN_00601

0.705

Your Current Organism:

Planoprotostelium fungivorum

NCBI taxonomy Id: 1890364
Other names: P. fungivorum, Planoprotostelium fungivorum Hillmann, Ferling, Novohradska & Gloeckner 2017, Protostelium sp. Jena Gg-2016a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PROFUN_00601	PROFUN_06210	A0A2P6NTZ0	A0A2P6MYZ7	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	0.531
PROFUN_00601	PROFUN_06527	A0A2P6NTZ0	A0A2P6NP02	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Uncharacterized protein; Belongs to the DOCK family.	0.998
PROFUN_00601	PROFUN_12544	A0A2P6NTZ0	A0A2P6N765	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	PPM-type phosphatase domain-containing protein; Belongs to the PP2C family.	0.705
PROFUN_00601	PROFUN_13787	A0A2P6NTZ0	A0A2P6N340	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Uncharacterized protein; Belongs to the actin family.	0.999
PROFUN_00601	PROFUN_14061	A0A2P6NTZ0	A0A2P6N1X6	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Actin related protein 2/3 complex, subunit 1.	0.999
PROFUN_02072	PROFUN_06527	A0A2P6NBB5	A0A2P6NP02	Uncharacterized protein.	Uncharacterized protein; Belongs to the DOCK family.	0.794
PROFUN_02072	PROFUN_12544	A0A2P6NBB5	A0A2P6N765	Uncharacterized protein.	PPM-type phosphatase domain-containing protein; Belongs to the PP2C family.	0.825
PROFUN_02072	PROFUN_13787	A0A2P6NBB5	A0A2P6N340	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.797
PROFUN_03347	PROFUN_06249	A0A2P6NWH6	A0A2P6NE48	Myosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Myosin-Vb-like.	0.706
PROFUN_03347	PROFUN_06527	A0A2P6NWH6	A0A2P6NP02	Myosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Uncharacterized protein; Belongs to the DOCK family.	0.760
PROFUN_03347	PROFUN_12544	A0A2P6NWH6	A0A2P6N765	Myosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	PPM-type phosphatase domain-containing protein; Belongs to the PP2C family.	0.749
PROFUN_03347	PROFUN_13787	A0A2P6NWH6	A0A2P6N340	Myosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Uncharacterized protein; Belongs to the actin family.	0.743
PROFUN_03347	PROFUN_14061	A0A2P6NWH6	A0A2P6N1X6	Myosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Actin related protein 2/3 complex, subunit 1.	0.583
PROFUN_06210	PROFUN_00601	A0A2P6MYZ7	A0A2P6NTZ0	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.531
PROFUN_06210	PROFUN_06527	A0A2P6MYZ7	A0A2P6NP02	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	Uncharacterized protein; Belongs to the DOCK family.	0.832
PROFUN_06210	PROFUN_12544	A0A2P6MYZ7	A0A2P6N765	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	PPM-type phosphatase domain-containing protein; Belongs to the PP2C family.	0.721
PROFUN_06210	PROFUN_13787	A0A2P6MYZ7	A0A2P6N340	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	Uncharacterized protein; Belongs to the actin family.	0.838
PROFUN_06210	PROFUN_14061	A0A2P6MYZ7	A0A2P6N1X6	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	Actin related protein 2/3 complex, subunit 1.	0.530
PROFUN_06249	PROFUN_03347	A0A2P6NE48	A0A2P6NWH6	Myosin-Vb-like.	Myosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.706
PROFUN_06249	PROFUN_06527	A0A2P6NE48	A0A2P6NP02	Myosin-Vb-like.	Uncharacterized protein; Belongs to the DOCK family.	0.667

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.949

expected number of edges:

18

PPI enrichment p-value:

6.48e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

8 of 71

1.56

2.62

7.29e-09

GO:0018106

Peptidyl-histidine phosphorylation

6 of 43

1.65

2.46

3.08e-07

GO:0009889

Regulation of biosynthetic process

8 of 212

1.08

1.25

2.00e-06

GO:0080090

Regulation of primary metabolic process

8 of 220

1.07

1.22

2.49e-06

GO:0050789

Regulation of biological process

10 of 329

0.99

1.16

1.34e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

7 of 46

1.69

2.83

2.23e-08

GO:0043565

Sequence-specific DNA binding

6 of 45

1.63

2.45

2.62e-07

GO:0003700

DNA-binding transcription factor activity

6 of 87

1.35

1.62

8.18e-06

GO:0003677

DNA binding

7 of 276

0.91

0.82

0.00024

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009986

Cell surface

6 of 30

1.81

3.03

3.13e-08

GO:0016021

Integral component of membrane

9 of 717

0.61

0.49

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5276

His Kinase A (phosphoacceptor) domain, and Transcriptional regulatory protein, C terminal

8 of 35

1.87

4.06

1.75e-11

CL:5278

His Kinase A (phosphoacceptor) domain, and Transcriptional regulatory protein, C terminal

7 of 27

1.92

3.94

1.71e-10

CL:5283

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and PAS fold-4

5 of 10

2.21

3.68

2.43e-08

CL:5280

His Kinase A (phosphoacceptor) domain, and Transcriptional regulatory protein, C terminal

6 of 22

1.94

3.52

5.66e-09

CL:5274

Signaling, and CheY-like superfamily

9 of 64

1.66

3.38

1.75e-11

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

9 of 365

0.9

0.92

7.85e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

6 of 76

1.41

1.7

1.01e-05

KW-0597

Phosphoprotein

4 of 45

1.46

1.25

0.00094

KW-0175

Coiled coil

5 of 221

0.86

0.55

0.0160

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

7 of 15

2.18

4.71

4.50e-11

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

7 of 15

2.18

4.71

4.50e-11

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

7 of 15

2.18

4.71

4.50e-11

IPR005467

Histidine kinase domain

7 of 22

2.01

4.23

1.02e-10

IPR003594

Histidine kinase/HSP90-like ATPase

7 of 24

1.97

4.09

1.38e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

8 of 21

2.09

5.36

1.20e-13

SM00387

Histidine kinase-like ATPases

8 of 34

1.88

4.36

1.63e-12

SM00091

PAS domain

3 of 3

2.51

2.56

1.58e-05

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 5

2.29

2.32

3.30e-05

SM00448

cheY-homologous receiver domain

3 of 42

1.36

0.94

0.0063

(more ...)

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