PROFUN_11503 protein (Planoprotostelium fungivorum)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

PROFUN_11503

MFS domain-containing protein. (513 aa)

Predicted Functional Partners:

PROFUN_05870

0.731

PROFUN_17166

0.611

PROFUN_04386

0.611

PROFUN_05003

0.574

PROFUN_09468

0.572

PROFUN_08461

0.560

PROFUN_04777

0.556

PROFUN_03788

0.554

PROFUN_10477

0.550

PROFUN_00881

0.550

Your Current Organism:

Planoprotostelium fungivorum

NCBI taxonomy Id: 1890364
Other names: P. fungivorum, Planoprotostelium fungivorum Hillmann, Ferling, Novohradska & Gloeckner 2017, Protostelium sp. Jena Gg-2016a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PROFUN_00881	PROFUN_03788	A0A2P6P0A6	A0A2P6NDQ8	Uncharacterized protein.	Uncharacterized protein.	0.994
PROFUN_00881	PROFUN_08461	A0A2P6P0A6	A0A2P6N1U8	Uncharacterized protein.	Integrator complex subunit 1.	0.995
PROFUN_00881	PROFUN_09468	A0A2P6P0A6	A0A2P6NH17	Uncharacterized protein.	Integrator complex subunit 9-like.	0.993
PROFUN_00881	PROFUN_10477	A0A2P6P0A6	A0A2P6NDE4	Uncharacterized protein.	Armadillo-like helical domain-containing protein.	0.993
PROFUN_00881	PROFUN_11503	A0A2P6P0A6	A0A2P6N9Y8	Uncharacterized protein.	MFS domain-containing protein.	0.550
PROFUN_03788	PROFUN_00881	A0A2P6NDQ8	A0A2P6P0A6	Uncharacterized protein.	Uncharacterized protein.	0.994
PROFUN_03788	PROFUN_08461	A0A2P6NDQ8	A0A2P6N1U8	Uncharacterized protein.	Integrator complex subunit 1.	0.998
PROFUN_03788	PROFUN_09468	A0A2P6NDQ8	A0A2P6NH17	Uncharacterized protein.	Integrator complex subunit 9-like.	0.998
PROFUN_03788	PROFUN_10477	A0A2P6NDQ8	A0A2P6NDE4	Uncharacterized protein.	Armadillo-like helical domain-containing protein.	0.966
PROFUN_03788	PROFUN_11503	A0A2P6NDQ8	A0A2P6N9Y8	Uncharacterized protein.	MFS domain-containing protein.	0.554
PROFUN_04386	PROFUN_04777	A0A2P6NHV4	A0A2P6NSW4	Stearic acid desaturase.	Cytochrome b2; Belongs to the cytochrome b5 family.	0.932
PROFUN_04386	PROFUN_05003	A0A2P6NHV4	A0A2P6NST6	Stearic acid desaturase.	Nitrate reductase.	0.968
PROFUN_04386	PROFUN_05870	A0A2P6NHV4	A0A2P6NKN4	Stearic acid desaturase.	Malate synthase.	0.654
PROFUN_04386	PROFUN_11503	A0A2P6NHV4	A0A2P6N9Y8	Stearic acid desaturase.	MFS domain-containing protein.	0.611
PROFUN_04386	PROFUN_17166	A0A2P6NHV4	A0A2P6MLZ2	Stearic acid desaturase.	Uncharacterized protein.	0.940
PROFUN_04777	PROFUN_04386	A0A2P6NSW4	A0A2P6NHV4	Cytochrome b2; Belongs to the cytochrome b5 family.	Stearic acid desaturase.	0.932
PROFUN_04777	PROFUN_05003	A0A2P6NSW4	A0A2P6NST6	Cytochrome b2; Belongs to the cytochrome b5 family.	Nitrate reductase.	0.951
PROFUN_04777	PROFUN_05870	A0A2P6NSW4	A0A2P6NKN4	Cytochrome b2; Belongs to the cytochrome b5 family.	Malate synthase.	0.986
PROFUN_04777	PROFUN_11503	A0A2P6NSW4	A0A2P6N9Y8	Cytochrome b2; Belongs to the cytochrome b5 family.	MFS domain-containing protein.	0.556
PROFUN_04777	PROFUN_17166	A0A2P6NSW4	A0A2P6MLZ2	Cytochrome b2; Belongs to the cytochrome b5 family.	Uncharacterized protein.	0.864

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

13

average node degree:

2.36

avg. local clustering coefficient:

0.855

expected number of edges:

11

PPI enrichment p-value:

0.263

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006352

DNA-templated transcription, initiation

5 of 25

1.83

2.2

1.35e-05

GO:0006281

DNA repair

4 of 60

1.35

1.15

0.0011

GO:0034654

Nucleobase-containing compound biosynthetic process

6 of 152

1.13

1.07

0.00024

GO:0090304

Nucleic acid metabolic process

9 of 316

0.98

1.02

1.35e-05

GO:0009059

Macromolecule biosynthetic process

6 of 256

0.9

0.73

0.0015

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016987

Sigma factor activity

5 of 25

1.83

2.3

7.03e-06

GO:0003700

DNA-binding transcription factor activity

6 of 75

1.43

1.72

1.22e-05

GO:0003677

DNA binding

7 of 267

0.95

0.84

0.00045

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5222

Oxoglutarate/iron-dependent dioxygenase, and methylated-DNA-[protein]-cysteine S-methyltransferase activity

3 of 5

2.31

1.63

0.00086

CL:5180

Mixed, incl. LysR, substrate-binding, and Pirin

4 of 35

1.59

1.29

0.0013

CL:2233

Mixed, incl. Sigma-70 factor, region 1.2, and Smr domain

2 of 6

2.05

0.78

0.0357

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

5 of 47

1.56

1.72

5.40e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0731

Sigma factor

4 of 23

1.77

1.88

7.09e-05

KW-0238

DNA-binding

7 of 150

1.2

1.36

1.20e-05

KW-0805

Transcription regulation

5 of 104

1.21

1.1

0.00053

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04545

Sigma-70, region 4

5 of 10

2.23

3.41

1.19e-07

PF00140

Sigma-70 factor, region 1.2

3 of 3

2.53

2.15

9.92e-05

PF04542

Sigma-70 region 2

4 of 20

1.83

1.87

9.92e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007630

RNA polymerase sigma-70 region 4

5 of 6

2.45

3.76

4.83e-08

IPR000943

RNA polymerase sigma-70

5 of 6

2.45

3.76

4.83e-08

IPR014284

RNA polymerase sigma-70 like domain

5 of 22

1.89

2.51

2.75e-06

IPR013324

RNA polymerase sigma factor, region 3/4-like

5 of 22

1.89

2.51

2.75e-06

IPR009042

RNA polymerase sigma-70 region 1.2

3 of 3

2.53

2.15

0.00010

(more ...)

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