PROFUN_11243 protein (Planoprotostelium fungivorum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PROFUN_11243

GDP-mannose transporter GONST2-like. (606 aa)

Predicted Functional Partners:

PROFUN_11317

0.542

PROFUN_02072

0.542

Your Current Organism:

Planoprotostelium fungivorum

NCBI taxonomy Id: 1890364
Other names: P. fungivorum, Planoprotostelium fungivorum Hillmann, Ferling, Novohradska & Gloeckner 2017, Protostelium sp. Jena Gg-2016a

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

29

PPI enrichment p-value:

3.86e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140662

ATP-dependent protein folding chaperone

5 of 20

2.47

4.06

1.21e-08

GO:0051082

Unfolded protein binding

5 of 61

1.98

2.85

6.68e-07

GO:0016887

ATP hydrolysis activity

5 of 176

1.52

1.62

8.21e-05

GO:0017018

Myosin phosphatase activity

2 of 18

2.11

0.95

0.0166

GO:0016787

Hydrolase activity

7 of 1495

0.74

0.51

0.0092

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005832

Chaperonin-containing T-complex

5 of 8

2.86

5.24

1.58e-10

GO:0005829

Cytosol

6 of 785

0.95

0.7

0.0049

GO:0005737

Cytoplasm

10 of 4274

0.44

0.31

0.0250

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7095

Mixed, incl. Chaperonin-mediated protein folding, and Apoptotic execution phase

8 of 31

2.48

7.21

9.54e-16

CL:7101

Chaperonin-containing T-complex

5 of 8

2.86

5.3

1.18e-10

CL:7133

Apoptotic execution phase, and Mob1/phocein family

3 of 5

2.85

2.75

9.12e-06

CL:7700

CTLA4 inhibitory signaling, and Positive regulation of dephosphorylation

3 of 7

2.7

2.59

1.63e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03018

RNA degradation

4 of 99

1.67

1.66

0.00018

map04136

Autophagy - other

2 of 28

1.92

1.03

0.0103

map03015

mRNA surveillance pathway

3 of 104

1.53

1.01

0.0065

map04113

Meiosis - yeast

3 of 140

1.4

0.88

0.0103

map04111

Cell cycle - yeast

3 of 153

1.36

0.86

0.0103

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6814122

Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

5 of 11

2.73

4.86

6.32e-10

MAP-390471

Association of TriC/CCT with target proteins during biosynthesis

5 of 11

2.73

4.86

6.32e-10

MAP-390466

Chaperonin-mediated protein folding

5 of 20

2.47

4.37

2.55e-09

MAP-391251

Protein folding

5 of 24

2.39

4.2

4.27e-09

MAP-6811558

PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

4 of 9

2.72

3.96

3.80e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005832

Chaperonin-containing T-complex

5 of 8

2.86

5.2

1.93e-10

GOCC:0030133

Transport vesicle

2 of 23

2.01

0.71

0.0471

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0143

Chaperone

5 of 22

2.42

4.3

3.05e-09

KW-0963

Cytoplasm

5 of 138

1.63

2.03

8.39e-06

KW-0067

ATP-binding

5 of 341

1.23

1.14

0.00045

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00118

TCP-1/cpn60 chaperonin family

5 of 10

2.77

4.95

4.62e-10

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017998

Chaperone tailless complex polypeptide 1 (TCP-1)

5 of 8

2.86

4.96

5.55e-10

IPR002194

Chaperonin TCP-1, conserved site

5 of 8

2.86

4.96

5.55e-10

IPR027413

GroEL-like equatorial domain superfamily

5 of 9

2.81

4.94

5.55e-10

IPR027410

TCP-1-like chaperonin intermediate domain superfamily

5 of 9

2.81

4.94

5.55e-10

IPR027409

GroEL-like apical domain superfamily

5 of 10

2.77

4.91

5.55e-10

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

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node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PROFUN_02072	PROFUN_11243	A0A2P6NBB5	A0A2P6NA50	Uncharacterized protein.	GDP-mannose transporter GONST2-like.	0.542
PROFUN_11243	PROFUN_02072	A0A2P6NA50	A0A2P6NBB5	GDP-mannose transporter GONST2-like.	Uncharacterized protein.	0.542
PROFUN_11243	PROFUN_11317	A0A2P6NA50	A0A2P6N2L5	GDP-mannose transporter GONST2-like.	Histone H2A deubiquitinase MYSM1.	0.542
PROFUN_11317	PROFUN_11243	A0A2P6N2L5	A0A2P6NA50	Histone H2A deubiquitinase MYSM1.	GDP-mannose transporter GONST2-like.	0.542

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