PROFUN_08957 protein (Planoprotostelium fungivorum)

Nodes:

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

PROFUN_08957

Uncharacterized protein. (499 aa)

Predicted Functional Partners:

PROFUN_08800

0.720

PROFUN_06261

0.622

PROFUN_11743

0.617

PROFUN_05449

0.617

PROFUN_02232

0.617

PROFUN_03216

0.599

PROFUN_16891

0.552

PROFUN_03545

0.552

PROFUN_16149

0.552

PROFUN_13002

0.552

Your Current Organism:

Planoprotostelium fungivorum

NCBI taxonomy Id: 1890364
Other names: P. fungivorum, Planoprotostelium fungivorum Hillmann, Ferling, Novohradska & Gloeckner 2017, Protostelium sp. Jena Gg-2016a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PROFUN_02232	PROFUN_03545	A0A2P6NYB5	A0A2P6MSE9	Uracil phosphoribosyltransferase.	Protein TTN-1, isoform d.	0.750
PROFUN_02232	PROFUN_05449	A0A2P6NYB5	A0A2P6NQZ9	Uracil phosphoribosyltransferase.	Uridine-cytidine kinase; Belongs to the uridine kinase family.	0.983
PROFUN_02232	PROFUN_06261	A0A2P6NYB5	A0A2P6NE71	Uracil phosphoribosyltransferase.	Uncharacterized protein.	0.630
PROFUN_02232	PROFUN_08800	A0A2P6NYB5	A0A2P6MVY2	Uracil phosphoribosyltransferase.	Uncharacterized protein.	0.799
PROFUN_02232	PROFUN_08957	A0A2P6NYB5	A0A2P6NIS8	Uracil phosphoribosyltransferase.	Uncharacterized protein.	0.617
PROFUN_02232	PROFUN_11743	A0A2P6NYB5	A0A2P6MYE9	Uracil phosphoribosyltransferase.	Uridine-cytidine kinase; Belongs to the uridine kinase family.	0.983
PROFUN_02232	PROFUN_13002	A0A2P6NYB5	A0A2P6N5U1	Uracil phosphoribosyltransferase.	Uncharacterized protein.	0.750
PROFUN_02232	PROFUN_16149	A0A2P6NYB5	A0A2P6MSN2	Uracil phosphoribosyltransferase.	Uncharacterized protein.	0.750
PROFUN_02232	PROFUN_16891	A0A2P6NYB5	A0A2P6MNJ0	Uracil phosphoribosyltransferase.	Uncharacterized protein.	0.750
PROFUN_03216	PROFUN_03545	A0A2P6NX27	A0A2P6MSE9	Nicotinamide riboside kinase.	Protein TTN-1, isoform d.	0.707
PROFUN_03216	PROFUN_06261	A0A2P6NX27	A0A2P6NE71	Nicotinamide riboside kinase.	Uncharacterized protein.	0.613
PROFUN_03216	PROFUN_08800	A0A2P6NX27	A0A2P6MVY2	Nicotinamide riboside kinase.	Uncharacterized protein.	0.760
PROFUN_03216	PROFUN_08957	A0A2P6NX27	A0A2P6NIS8	Nicotinamide riboside kinase.	Uncharacterized protein.	0.599
PROFUN_03216	PROFUN_13002	A0A2P6NX27	A0A2P6N5U1	Nicotinamide riboside kinase.	Uncharacterized protein.	0.707
PROFUN_03216	PROFUN_16149	A0A2P6NX27	A0A2P6MSN2	Nicotinamide riboside kinase.	Uncharacterized protein.	0.707
PROFUN_03216	PROFUN_16891	A0A2P6NX27	A0A2P6MNJ0	Nicotinamide riboside kinase.	Uncharacterized protein.	0.707
PROFUN_03545	PROFUN_02232	A0A2P6MSE9	A0A2P6NYB5	Protein TTN-1, isoform d.	Uracil phosphoribosyltransferase.	0.750
PROFUN_03545	PROFUN_03216	A0A2P6MSE9	A0A2P6NX27	Protein TTN-1, isoform d.	Nicotinamide riboside kinase.	0.707
PROFUN_03545	PROFUN_05449	A0A2P6MSE9	A0A2P6NQZ9	Protein TTN-1, isoform d.	Uridine-cytidine kinase; Belongs to the uridine kinase family.	0.750
PROFUN_03545	PROFUN_08800	A0A2P6MSE9	A0A2P6MVY2	Protein TTN-1, isoform d.	Uncharacterized protein.	0.764

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.728

expected number of edges:

14

PPI enrichment p-value:

7.78e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006605

Protein targeting

7 of 11

2.24

5.28

2.99e-12

GO:0015031

Protein transport

10 of 38

1.86

4.84

4.37e-15

GO:0065002

Intracellular protein transmembrane transport

5 of 7

2.29

3.89

1.28e-08

GO:0043952

Protein transport by the Sec complex

4 of 4

2.44

3.29

4.55e-07

GO:0090150

Establishment of protein localization to membrane

3 of 14

1.77

1.39

0.0013

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008320

Protein transmembrane transporter activity

6 of 8

2.31

4.45

7.26e-10

GO:0015450

Protein-transporting ATPase activity

4 of 6

2.26

2.82

2.73e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

8 of 465

0.67

0.5

0.0045

GO:0016020

Membrane

9 of 918

0.43

0.3

0.0284

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:302

SRP54-type protein, GTPase domain, and Translocation

5 of 5

2.44

4.23

4.58e-09

CL:122

Ribosome, and Translation regulator activity

11 of 98

1.49

3.06

5.54e-14

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03060

Protein export

10 of 20

2.13

6.92

2.23e-18

map03070

Bacterial secretion system

10 of 25

2.04

6.32

6.79e-18

map02024

Quorum sensing

8 of 93

1.37

2.13

6.93e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

6 of 34

1.68

2.8

2.31e-08

MAP-9635486

Infection with Mycobacterium tuberculosis

6 of 51

1.51

2.27

1.06e-07

MAP-5663205

Infectious disease

6 of 53

1.49

2.24

1.06e-07

MAP-1643685

Disease

6 of 53

1.49

2.24

1.06e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031522

Cell envelope Sec protein transport complex

2 of 2

2.44

1.0

0.0145

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

7 of 7

2.44

6.13

2.25e-13

KW-0653

Protein transport

8 of 13

2.22

5.94

3.54e-14

KW-1003

Cell membrane

9 of 164

1.17

1.61

1.64e-08

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00963

SRP54-type protein, helical bundle domain

2 of 2

2.44

1.15

0.0077

SM00962

SRP54-type protein, GTPase domain

2 of 2

2.44

1.15

0.0077

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