PROFUN_08295 protein (Planoprotostelium fungivorum)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

PROFUN_08295

Protein kinase domain-containing protein. (1409 aa)

Predicted Functional Partners:

PROFUN_10073

0.566

PROFUN_10622

0.541

PROFUN_14185

0.535

PROFUN_07190

0.535

PROFUN_09804

0.519

PROFUN_07830

0.513

PROFUN_01983

0.500

PROFUN_10649

0.500

PROFUN_08397

0.500

PROFUN_02223

0.475

Your Current Organism:

Planoprotostelium fungivorum

NCBI taxonomy Id: 1890364
Other names: P. fungivorum, Planoprotostelium fungivorum Hillmann, Ferling, Novohradska & Gloeckner 2017, Protostelium sp. Jena Gg-2016a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PROFUN_01983	PROFUN_07190	A0A2P6NB35	A0A2P6NMF3	WD_REPEATS_REGION domain-containing protein.	Putative ankyrin repeat protein.	0.977
PROFUN_01983	PROFUN_07830	A0A2P6NB35	A0A2P6NLD0	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.557
PROFUN_01983	PROFUN_08295	A0A2P6NB35	A0A2P6NJY7	WD_REPEATS_REGION domain-containing protein.	Protein kinase domain-containing protein.	0.500
PROFUN_01983	PROFUN_10073	A0A2P6NB35	A0A2P6NEW1	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.565
PROFUN_01983	PROFUN_10622	A0A2P6NB35	A0A2P6ND81	WD_REPEATS_REGION domain-containing protein.	Baculoviral IAP repeat-containing protein 6.	0.974
PROFUN_01983	PROFUN_14185	A0A2P6NB35	A0A2P6N0Q2	WD_REPEATS_REGION domain-containing protein.	Putative ankyrin repeat-containing protein.	0.977
PROFUN_02223	PROFUN_08295	A0A2P6NZJ9	A0A2P6NJY7	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.475
PROFUN_07190	PROFUN_01983	A0A2P6NMF3	A0A2P6NB35	Putative ankyrin repeat protein.	WD_REPEATS_REGION domain-containing protein.	0.977
PROFUN_07190	PROFUN_07830	A0A2P6NMF3	A0A2P6NLD0	Putative ankyrin repeat protein.	Uncharacterized protein.	0.580
PROFUN_07190	PROFUN_08295	A0A2P6NMF3	A0A2P6NJY7	Putative ankyrin repeat protein.	Protein kinase domain-containing protein.	0.535
PROFUN_07190	PROFUN_08397	A0A2P6NMF3	A0A2P6NJS3	Putative ankyrin repeat protein.	Uncharacterized protein.	0.977
PROFUN_07190	PROFUN_10073	A0A2P6NMF3	A0A2P6NEW1	Putative ankyrin repeat protein.	Uncharacterized protein.	0.746
PROFUN_07190	PROFUN_10622	A0A2P6NMF3	A0A2P6ND81	Putative ankyrin repeat protein.	Baculoviral IAP repeat-containing protein 6.	0.723
PROFUN_07190	PROFUN_10649	A0A2P6NMF3	A0A2P6NCU1	Putative ankyrin repeat protein.	Uncharacterized protein.	0.977
PROFUN_07190	PROFUN_14185	A0A2P6NMF3	A0A2P6N0Q2	Putative ankyrin repeat protein.	Putative ankyrin repeat-containing protein.	0.451
PROFUN_07830	PROFUN_01983	A0A2P6NLD0	A0A2P6NB35	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.557
PROFUN_07830	PROFUN_07190	A0A2P6NLD0	A0A2P6NMF3	Uncharacterized protein.	Putative ankyrin repeat protein.	0.580
PROFUN_07830	PROFUN_08295	A0A2P6NLD0	A0A2P6NJY7	Uncharacterized protein.	Protein kinase domain-containing protein.	0.513
PROFUN_07830	PROFUN_08397	A0A2P6NLD0	A0A2P6NJS3	Uncharacterized protein.	Uncharacterized protein.	0.557
PROFUN_07830	PROFUN_09804	A0A2P6NLD0	A0A2P6NGP0	Uncharacterized protein.	IPPc domain-containing protein.	0.491

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.874

expected number of edges:

13

PPI enrichment p-value:

2.92e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006099

Tricarboxylic acid cycle

7 of 30

2.41

5.72

1.63e-12

GO:0019752

Carboxylic acid metabolic process

9 of 784

1.1

1.33

6.30e-07

GO:0006108

Malate metabolic process

2 of 6

2.56

1.2

0.0064

GO:0044238

Primary metabolic process

11 of 4221

0.46

0.36

0.0034

GO:0044237

Cellular metabolic process

11 of 4447

0.43

0.34

0.0055

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046912

Acyltransferase activity, acyl groups converted into alkyl on transfer

3 of 10

2.52

1.93

0.00026

GO:0030060

L-malate dehydrogenase activity

2 of 2

3.04

1.35

0.0037

GO:0004108

Citrate (Si)-synthase activity

2 of 2

3.04

1.35

0.0037

GO:0000104

Succinate dehydrogenase activity

2 of 4

2.74

1.34

0.0037

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005739

Mitochondrion

7 of 1023

0.88

0.63

0.0064

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14830

Tricarboxylic acid cycle, and ATP citrate synthase activity

6 of 19

2.54

5.29

3.99e-11

CL:14812

Mixed, incl. Citrate cycle (TCA cycle), and Branched-chain amino acid catabolic process

7 of 67

2.06

4.43

5.51e-11

CL:14833

Citrate synthase, and Malate dehydrogenase, type 1

4 of 7

2.8

4.05

2.89e-08

CL:14802

Mixed, incl. 2-Oxocarboxylic acid metabolism, and Citrate cycle (TCA cycle)

8 of 134

1.82

3.8

5.04e-11

CL:14852

Fumarate reductase complex, and 3Fe-4S

2 of 5

2.64

1.35

0.0034

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00020

Citrate cycle (TCA cycle)

7 of 51

2.18

5.31

9.92e-13

map00630

Glyoxylate and dicarboxylate metabolism

7 of 90

1.93

4.19

2.79e-11

map01200

Carbon metabolism

10 of 217

1.71

4.12

7.30e-15

map00620

Pyruvate metabolism

4 of 113

1.59

1.7

7.97e-05

map01210

2-Oxocarboxylic acid metabolism

3 of 91

1.56

1.25

0.0016

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-71403

Citric acid cycle (TCA cycle)

6 of 55

2.08

3.76

5.39e-09

MAP-71406

Pyruvate metabolism and Citric Acid (TCA) cycle

6 of 81

1.91

3.25

2.43e-08

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

6 of 162

1.61

2.27

8.89e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0816

Tricarboxylic acid cycle

2 of 8

2.44

1.14

0.0082

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02866

Lactate/malate dehydrogenase, alpha/beta C-terminal domain

2 of 2

3.04

1.28

0.0049

PF00285

Citrate synthase, C-terminal domain

2 of 3

2.87

1.28

0.0049

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR022383

Lactate/malate dehydrogenase, C-terminal

2 of 2

3.04

1.04

0.0136

IPR019810

Citrate synthase active site

2 of 2

3.04

1.04

0.0136

IPR016142

Citrate synthase-like, large alpha subdomain

2 of 2

3.04

1.04

0.0136

IPR015955

Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

2 of 2

3.04

1.04

0.0136

IPR010097

Malate dehydrogenase, type 1

2 of 2

3.04

1.04

0.0136

(more ...)

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