STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PROFUN_07872D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (523 aa)    
Predicted Functional Partners:
PROFUN_06013
Phosphoserine aminotransferase.
 
 0.984
PROFUN_10075
Tryptophane synthase.
  
 0.956
PROFUN_05870
Malate synthase.
    
 0.928
PROFUN_04777
Cytochrome b2; Belongs to the cytochrome b5 family.
  
 
 0.885
PROFUN_13196
Phosphoglycerate mutase.
    
 0.851
PROFUN_02648
Phosphoglycerate mutase.
    
 0.851
PROFUN_04989
AB hydrolase-1 domain-containing protein.
  
 0.846
PROFUN_02610
AB hydrolase-1 domain-containing protein.
  
 0.846
PROFUN_11295
Bifunctional dihydrofolate reductase-thymidylate synthase.
  
 0.776
PROFUN_15120
Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.
  
 0.752
Your Current Organism:
Planoprotostelium fungivorum
NCBI taxonomy Id: 1890364
Other names: P. fungivorum, Planoprotostelium fungivorum Hillmann, Ferling, Novohradska & Gloeckner 2017, Protostelium sp. Jena Gg-2016a
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