PROFUN_01867 protein (Planoprotostelium fungivorum)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

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protein homology

Your Input:

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[Homology]

Score

PROFUN_01867

WW domain-containing protein. (452 aa)

Predicted Functional Partners:

PROFUN_00025

0.879

PROFUN_14858

0.840

PROFUN_13658

0.840

PROFUN_09143

0.823

PROFUN_04127

0.785

PROFUN_04626

0.785

PROFUN_01362

0.777

PROFUN_08776

0.737

PROFUN_14335

0.737

PROFUN_10622

0.724

Your Current Organism:

Planoprotostelium fungivorum

NCBI taxonomy Id: 1890364
Other names: P. fungivorum, Planoprotostelium fungivorum Hillmann, Ferling, Novohradska & Gloeckner 2017, Protostelium sp. Jena Gg-2016a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PROFUN_00025	PROFUN_01362	A0A2P6P0E6	A0A2P6P000	Ubiquitin.	Putative 26S proteasome non-atpase regulatory subunit.	0.996
PROFUN_00025	PROFUN_01867	A0A2P6P0E6	A0A2P6NYV8	Ubiquitin.	WW domain-containing protein.	0.879
PROFUN_00025	PROFUN_04127	A0A2P6P0E6	A0A2P6NJK0	Ubiquitin.	Ubiquitin-like domain-containing protein.	0.991
PROFUN_00025	PROFUN_04626	A0A2P6P0E6	A0A2P6NUF7	Ubiquitin.	Ribosomal protein L40.	0.996
PROFUN_00025	PROFUN_08776	A0A2P6P0E6	A0A2P6MVP6	Ubiquitin.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.806
PROFUN_00025	PROFUN_10622	A0A2P6P0E6	A0A2P6ND81	Ubiquitin.	Baculoviral IAP repeat-containing protein 6.	0.999
PROFUN_00025	PROFUN_13658	A0A2P6P0E6	A0A2P6N3F4	Ubiquitin.	Uncharacterized protein.	0.572
PROFUN_00025	PROFUN_14335	A0A2P6P0E6	A0A2P6N0G8	Ubiquitin.	PI3K/PI4K domain-containing protein.	0.806
PROFUN_00025	PROFUN_14858	A0A2P6P0E6	A0A2P6MYP9	Ubiquitin.	Uncharacterized protein.	0.572
PROFUN_01362	PROFUN_00025	A0A2P6P000	A0A2P6P0E6	Putative 26S proteasome non-atpase regulatory subunit.	Ubiquitin.	0.996
PROFUN_01362	PROFUN_01867	A0A2P6P000	A0A2P6NYV8	Putative 26S proteasome non-atpase regulatory subunit.	WW domain-containing protein.	0.777
PROFUN_01362	PROFUN_04127	A0A2P6P000	A0A2P6NJK0	Putative 26S proteasome non-atpase regulatory subunit.	Ubiquitin-like domain-containing protein.	0.940
PROFUN_01362	PROFUN_04626	A0A2P6P000	A0A2P6NUF7	Putative 26S proteasome non-atpase regulatory subunit.	Ribosomal protein L40.	0.940
PROFUN_01362	PROFUN_08776	A0A2P6P000	A0A2P6MVP6	Putative 26S proteasome non-atpase regulatory subunit.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.892
PROFUN_01362	PROFUN_10622	A0A2P6P000	A0A2P6ND81	Putative 26S proteasome non-atpase regulatory subunit.	Baculoviral IAP repeat-containing protein 6.	0.716
PROFUN_01362	PROFUN_14335	A0A2P6P000	A0A2P6N0G8	Putative 26S proteasome non-atpase regulatory subunit.	PI3K/PI4K domain-containing protein.	0.892
PROFUN_01867	PROFUN_00025	A0A2P6NYV8	A0A2P6P0E6	WW domain-containing protein.	Ubiquitin.	0.879
PROFUN_01867	PROFUN_01362	A0A2P6NYV8	A0A2P6P000	WW domain-containing protein.	Putative 26S proteasome non-atpase regulatory subunit.	0.777
PROFUN_01867	PROFUN_04127	A0A2P6NYV8	A0A2P6NJK0	WW domain-containing protein.	Ubiquitin-like domain-containing protein.	0.785
PROFUN_01867	PROFUN_04626	A0A2P6NYV8	A0A2P6NUF7	WW domain-containing protein.	Ribosomal protein L40.	0.785

page 1 of 4

Network Stats

number of nodes:

6

number of edges:

15

average node degree:

5

avg. local clustering coefficient:

1

expected number of edges:

5

PPI enrichment p-value:

0.000158

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007178

Transmembrane receptor protein serine/threonine kinase signaling pathway

3 of 47

2.4

1.92

0.00025

GO:0007167

Enzyme-linked receptor protein signaling pathway

4 of 308

1.71

1.52

0.00051

GO:0048856

Anatomical structure development

8 of 1806

1.24

1.47

5.79e-06

GO:0009653

Anatomical structure morphogenesis

5 of 678

1.46

1.39

0.00035

GO:0032501

Multicellular organismal process

8 of 2133

1.17

1.33

9.65e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005515

Protein binding

7 of 4320

0.81

0.45

0.0410

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005925

Focal adhesion

4 of 48

2.52

3.3

5.25e-07

GO:0071944

Cell periphery

7 of 2782

1.0

0.93

0.00021

GO:0009986

Cell surface

2 of 75

2.02

0.92

0.0185

GO:0016020

Membrane

10 of 5623

0.85

0.86

3.79e-06

GO:0098552

Side of membrane

2 of 107

1.87

0.82

0.0270

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37179535

(2023) Engineered dual affinity protein fragments to bind collagen and capture growth factors.

2 of 2

3.6

1.5

0.0020

PMID:36247529

(2022) Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration.

2 of 3

3.42

1.5

0.0020

PMID:35386347

(2022) An overview of substrate stiffness guided cellular response and its applications in tissue regeneration.

2 of 4

3.3

1.5

0.0020

PMID:35053383

(2022) Scaffold-Mediated Immunoengineering as Innovative Strategy for Tendon Regeneration.

2 of 3

3.42

1.5

0.0020

PMID:34945337

(2021) Low Intensity Pulsed Ultrasound for Bone Tissue Engineering.

2 of 3

3.42

1.5

0.0020

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20631

Mixed, incl. EGF-like domain, extracellular, and GAIN domain, N-terminal

4 of 17

2.97

3.95

5.62e-08

CL:18025

Integrin complex, and Cell-extracellular matrix interactions

4 of 29

2.74

3.69

1.28e-07

CL:20633

EGF-like domain, extracellular, and G-protein-coupled receptor proteolytic site domain

3 of 11

3.03

3.22

1.33e-06

CL:18061

Alpha-catenin/vinculin-like superfamily, and Integrin beta subunits (N-terminal portion of extracellular region)

2 of 5

3.2

2.09

0.00017

CL:17275

Mixed, incl. Signal complex assembly, and Actin cytoskeleton reorganization

2 of 6

3.12

2.02

0.00022

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-194138

Signaling by VEGF

7 of 66

2.62

7.06

9.11e-15

MAP-114608

Platelet degranulation

6 of 88

2.43

5.29

1.97e-11

MAP-76005

Response to elevated platelet cytosolic Ca2+

6 of 90

2.42

5.27

1.97e-11

MAP-76002

Platelet activation, signaling and aggregation

6 of 188

2.1

4.14

6.56e-10

MAP-9006934

Signaling by Receptor Tyrosine Kinases

7 of 336

1.92

3.95

1.42e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070161

Anchoring junction

3 of 269

1.64

0.69

0.0430

GOCC:0110165

Cellular anatomical entity

11 of 18558

0.37

0.26

0.0483

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0245

EGF-like domain

4 of 267

1.77

1.8

0.00012

KW-1015

Disulfide bond

5 of 1000

1.3

1.23

0.00035

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013111

EGF-like domain, extracellular

4 of 21

2.88

3.73

1.29e-07

IPR042635

MEGF10/SREC1/2-like

2 of 6

3.12

1.44

0.0025

IPR000742

EGF-like domain

4 of 287

1.74

1.36

0.0014

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00181

Epidermal growth factor-like domain.

4 of 253

1.8

1.73

0.00020

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