cycA_1 protein (Fuerstia marisgermanicae) - STRING interaction network

Nodes:

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:

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[Homology]

Score

cycA_1

Hydroxylamine oxidoreductase-linked cytochrome. (1207 aa)

Predicted Functional Partners:

APZ92336.1

0.942

ctaD

0.899

ctaC

0.868

APZ94633.1

0.730

APZ93156.1

0.725

APZ93654.1

0.656

APZ96166.1

0.647

APZ96623.1

0.640

APZ92775.1

0.611

gfo_2

0.597

Your Current Organism:

Fuerstia marisgermanicae

NCBI taxonomy Id: 1891926
Other names: DSM 27554, F. marisgermanicae, LMG 27831, LMG:27831, Planctomycetes bacterium NH11, strain NH11

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ92336.1	APZ93156.1	Fuma_01946	Fuma_02772	Trehalose utilization.	Putative membrane-bound dehydrogenase domain protein.	0.584
APZ92336.1	APZ94633.1	Fuma_01946	Fuma_04266	Trehalose utilization.	Putative membrane-bound dehydrogenase domain protein.	0.660
APZ92336.1	APZ96166.1	Fuma_01946	Fuma_05834	Trehalose utilization.	Major Facilitator Superfamily protein.	0.624
APZ92336.1	APZ96623.1	Fuma_01946	Fuma_06296	Trehalose utilization.	Xylose isomerase-like TIM barrel.	0.723
APZ92336.1	cycA_1	Fuma_01946	Fuma_00644	Trehalose utilization.	Hydroxylamine oxidoreductase-linked cytochrome.	0.942
APZ92336.1	gfo_2	Fuma_01946	Fuma_01684	Trehalose utilization.	Glucose--fructose oxidoreductase precursor.	0.483
APZ92775.1	APZ93654.1	Fuma_02387	Fuma_03272	NPCBM/NEW2 domain protein.	Type I secretion outer membrane protein, TolC family.	0.716
APZ92775.1	APZ96166.1	Fuma_02387	Fuma_05834	NPCBM/NEW2 domain protein.	Major Facilitator Superfamily protein.	0.664
APZ92775.1	cycA_1	Fuma_02387	Fuma_00644	NPCBM/NEW2 domain protein.	Hydroxylamine oxidoreductase-linked cytochrome.	0.611
APZ93156.1	APZ92336.1	Fuma_02772	Fuma_01946	Putative membrane-bound dehydrogenase domain protein.	Trehalose utilization.	0.584
APZ93156.1	cycA_1	Fuma_02772	Fuma_00644	Putative membrane-bound dehydrogenase domain protein.	Hydroxylamine oxidoreductase-linked cytochrome.	0.725
APZ93156.1	gfo_2	Fuma_02772	Fuma_01684	Putative membrane-bound dehydrogenase domain protein.	Glucose--fructose oxidoreductase precursor.	0.632
APZ93654.1	APZ92775.1	Fuma_03272	Fuma_02387	Type I secretion outer membrane protein, TolC family.	NPCBM/NEW2 domain protein.	0.716
APZ93654.1	cycA_1	Fuma_03272	Fuma_00644	Type I secretion outer membrane protein, TolC family.	Hydroxylamine oxidoreductase-linked cytochrome.	0.656
APZ94633.1	APZ92336.1	Fuma_04266	Fuma_01946	Putative membrane-bound dehydrogenase domain protein.	Trehalose utilization.	0.660
APZ94633.1	APZ96166.1	Fuma_04266	Fuma_05834	Putative membrane-bound dehydrogenase domain protein.	Major Facilitator Superfamily protein.	0.653
APZ94633.1	cycA_1	Fuma_04266	Fuma_00644	Putative membrane-bound dehydrogenase domain protein.	Hydroxylamine oxidoreductase-linked cytochrome.	0.730
APZ94633.1	gfo_2	Fuma_04266	Fuma_01684	Putative membrane-bound dehydrogenase domain protein.	Glucose--fructose oxidoreductase precursor.	0.628
APZ96166.1	APZ92336.1	Fuma_05834	Fuma_01946	Major Facilitator Superfamily protein.	Trehalose utilization.	0.624
APZ96166.1	APZ92775.1	Fuma_05834	Fuma_02387	Major Facilitator Superfamily protein.	NPCBM/NEW2 domain protein.	0.664

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.945

expected number of edges:

13

PPI enrichment p-value:

0.000238

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005985

Sucrose metabolic process

3 of 3

2.23

1.38

0.0025

GO:0009401

Phosphoenolpyruvate-dependent sugar phosphotransferase system

4 of 28

1.39

0.96

0.0060

GO:0005975

Carbohydrate metabolic process

6 of 138

0.87

0.63

0.0060

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004564

Beta-fructofuranosidase activity

3 of 3

2.23

1.65

0.00074

GO:0008982

protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

4 of 21

1.51

1.3

0.00088

GO:0004553

Hydrolase activity, hydrolyzing O-glycosyl compounds

5 of 36

1.38

1.22

0.00074

GO:0016773

Phosphotransferase activity, alcohol group as acceptor

5 of 58

1.17

1.0

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1197

Mixed, incl. Glycosidase, and Amino sugar metabolic process

7 of 16

1.87

3.76

2.85e-10

CL:1196

Import across plasma membrane, and Glycosidase

9 of 31

1.7

3.64

3.74e-12

CL:1195

Mixed, incl. Phosphotransferase system (PTS), and Pentose phosphate pathway

10 of 60

1.46

2.76

3.84e-12

CL:1194

Mixed, incl. Phosphotransferase system (PTS), and Glycolysis / Gluconeogenesis

11 of 83

1.36

2.45

1.10e-12

CL:1218

Glycosidase, and Mannose-6-phosphate isomerase, type I

2 of 5

1.84

0.79

0.0308

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00500

Starch and sucrose metabolism

6 of 69

1.17

0.00012

map02060

Phosphotransferase system (PTS)

4 of 30

1.36

1.14

0.0013

map00051

Fructose and mannose metabolism

3 of 21

1.39

0.89

0.0091

map00052

Galactose metabolism

3 of 25

1.31

0.83

0.0109

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0326

Glycosidase

4 of 13

1.72

1.66

0.00022

KW-0598

Phosphotransferase system

3 of 12

1.63

1.09

0.0050

KW-0119

Carbohydrate metabolism

3 of 19

1.43

0.88

0.0111

KW-0762

Sugar transport

2 of 7

1.69

0.7

0.0426

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00367

Phosphotransferase system, EIIB

2 of 2

2.23

0.71

0.0495

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023296

Glycosyl hydrolase, five-bladed beta-propellor domain superfamily

3 of 3

2.23

1.39

0.0024

IPR013189

Glycosyl hydrolase family 32, C-terminal

3 of 3

2.23

1.39

0.0024

IPR013148

Glycosyl hydrolase family 32, N-terminal

3 of 3

2.23

1.39

0.0024

IPR006232

Sucrose-6-phosphate hydrolase

3 of 3

2.23

1.39

0.0024

IPR001362

Glycoside hydrolase, family 32

3 of 3

2.23

1.39

0.0024

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00640

Glycosyl hydrolases family 32

3 of 3

2.23

1.9

0.00023

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