STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mutMUnannotated protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (275 aa)    
Predicted Functional Partners:
polA
Unannotated protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
  
 0.984
coaE
Unannotated protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
 
  
 0.980
AF331_00895
Unannotated protein; Probably functions as a manganese efflux pump.
 
    0.793
nth
Unannotated protein; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
   
  
 0.724
AF331_03545
Unannotated protein.
 
  
 0.637
uvrC
Unannotated protein; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 
 
 0.596
GCA_900166615_04152
Unannotated protein.
  
  
 0.594
AF331_05455
Unannotated protein.
  
 
 0.490
AF331_00880
Unannotated protein; HflC and HflK could regulate a protease.
       0.488
AF331_00875
Unannotated protein; HflC and HflK could encode or regulate a protease.
       0.488
Your Current Organism:
Bacillus marisflavi
NCBI taxonomy Id: 189381
Other names: B. marisflavi, Bacillus marisflavi Yoon et al. 2003, Bacillus sp. JP44SK15, Bacillus sp. JP44SK40, Bacillus sp. LK16, Bacillus sp. LK19, Bacillus sp. LK26, JCM 11544, KCCM 41588, strain TF-11
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.