node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KOG68240.1 | KOG72546.1 | ADK78_37645 | ADK78_18850 | Flavohemoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.982 |
KOG68240.1 | KOG72577.1 | ADK78_37645 | ADK78_19050 | Flavohemoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
KOG68240.1 | carB | ADK78_37645 | ADK78_19055 | Flavohemoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Carbamoyl phosphate synthase large subunit; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.994 |
KOG68240.1 | guaA | ADK78_37645 | ADK78_20190 | Flavohemoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.958 |
KOG68240.1 | prs | ADK78_37645 | ADK78_18450 | Flavohemoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.758 |
KOG68240.1 | pyrB | ADK78_37645 | ADK78_19075 | Flavohemoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.992 |
KOG68240.1 | pyrC | ADK78_37645 | ADK78_19070 | Flavohemoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.980 |
KOG68240.1 | pyrE | ADK78_37645 | ADK78_10730 | Flavohemoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.996 |
KOG68240.1 | pyrF | ADK78_37645 | ADK78_19045 | Flavohemoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Orotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.992 |
KOG68240.1 | pyrR | ADK78_37645 | ADK78_19080 | Flavohemoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. | 0.962 |
KOG72546.1 | KOG68240.1 | ADK78_18850 | ADK78_37645 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Flavohemoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.982 |
KOG72546.1 | KOG72577.1 | ADK78_18850 | ADK78_19050 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.993 |
KOG72546.1 | carB | ADK78_18850 | ADK78_19055 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Carbamoyl phosphate synthase large subunit; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.993 |
KOG72546.1 | guaA | ADK78_18850 | ADK78_20190 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.998 |
KOG72546.1 | prs | ADK78_18850 | ADK78_18450 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.994 |
KOG72546.1 | pyrB | ADK78_18850 | ADK78_19075 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.995 |
KOG72546.1 | pyrC | ADK78_18850 | ADK78_19070 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.953 |
KOG72546.1 | pyrE | ADK78_18850 | ADK78_10730 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.995 |
KOG72546.1 | pyrF | ADK78_18850 | ADK78_19045 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Orotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.996 |
KOG72546.1 | pyrR | ADK78_18850 | ADK78_19080 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. | 0.986 |