node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KOG68507.1 | KOG68534.1 | ADK78_36345 | ADK78_36330 | Imidazole glycerol phosphate synthase subunit HisH; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
KOG68507.1 | KOG72714.1 | ADK78_36345 | ADK78_18865 | Imidazole glycerol phosphate synthase subunit HisH; Derived by automated computational analysis using gene prediction method: Protein Homology. | DeoR faimly transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.847 |
KOG68507.1 | hisB | ADK78_36345 | ADK78_36335 | Imidazole glycerol phosphate synthase subunit HisH; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
KOG68507.1 | hisD | ADK78_36345 | ADK78_36325 | Imidazole glycerol phosphate synthase subunit HisH; Derived by automated computational analysis using gene prediction method: Protein Homology. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
KOG68507.1 | hisE | ADK78_36345 | ADK78_18840 | Imidazole glycerol phosphate synthase subunit HisH; Derived by automated computational analysis using gene prediction method: Protein Homology. | phosphoribosyl-ATP pyrophosphatase; Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.997 |
KOG68507.1 | hisF | ADK78_36345 | ADK78_36360 | Imidazole glycerol phosphate synthase subunit HisH; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
KOG68507.1 | hisG | ADK78_36345 | ADK78_18835 | Imidazole glycerol phosphate synthase subunit HisH; Derived by automated computational analysis using gene prediction method: Protein Homology. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.999 |
KOG68507.1 | hisI | ADK78_36345 | ADK78_36420 | Imidazole glycerol phosphate synthase subunit HisH; Derived by automated computational analysis using gene prediction method: Protein Homology. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
KOG68507.1 | priA | ADK78_36345 | ADK78_36350 | Imidazole glycerol phosphate synthase subunit HisH; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoribosyl isomerase; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | 0.999 |
KOG68507.1 | prs | ADK78_36345 | ADK78_18450 | Imidazole glycerol phosphate synthase subunit HisH; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.873 |
KOG68534.1 | KOG68507.1 | ADK78_36330 | ADK78_36345 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazole glycerol phosphate synthase subunit HisH; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
KOG68534.1 | KOG72714.1 | ADK78_36330 | ADK78_18865 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | DeoR faimly transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.905 |
KOG68534.1 | hisB | ADK78_36330 | ADK78_36335 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
KOG68534.1 | hisD | ADK78_36330 | ADK78_36325 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
KOG68534.1 | hisE | ADK78_36330 | ADK78_18840 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | phosphoribosyl-ATP pyrophosphatase; Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.984 |
KOG68534.1 | hisF | ADK78_36330 | ADK78_36360 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
KOG68534.1 | hisG | ADK78_36330 | ADK78_18835 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.999 |
KOG68534.1 | hisI | ADK78_36330 | ADK78_36420 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.998 |
KOG68534.1 | priA | ADK78_36330 | ADK78_36350 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoribosyl isomerase; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | 0.999 |
KOG68534.1 | prs | ADK78_36330 | ADK78_18450 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.895 |