node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KOG67347.1 | KOG68273.1 | ADK78_41100 | ADK78_37515 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
KOG67347.1 | KOG68900.1 | ADK78_41100 | ADK78_34985 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | DNA polymerase I; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.781 |
KOG67347.1 | KOG69584.1 | ADK78_41100 | ADK78_32925 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Pyridoxal-5'-phosphate-dependent protein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.998 |
KOG67347.1 | KOG69818.1 | ADK78_41100 | ADK78_31860 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminoglycoside phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.972 |
KOG67347.1 | KOG72805.1 | ADK78_41100 | ADK78_18685 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
KOG67347.1 | KOG79106.1 | ADK78_41100 | ADK78_06745 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Molybdopterin biosynthesis-like protein MoeZ; The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; Derived by automated computational analysis using gene prediction method: Protein [...] | 0.956 |
KOG67347.1 | KOG79761.1 | ADK78_41100 | ADK78_05930 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
KOG67347.1 | KOG80819.1 | ADK78_41100 | ADK78_04575 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
KOG67347.1 | KOG81924.1 | ADK78_41100 | ADK78_03445 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine/threonine protein kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.922 |
KOG67347.1 | gcvP | ADK78_41100 | ADK78_02985 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.998 |
KOG68273.1 | KOG67347.1 | ADK78_37515 | ADK78_41100 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
KOG68273.1 | KOG68900.1 | ADK78_37515 | ADK78_34985 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | DNA polymerase I; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
KOG68273.1 | KOG69584.1 | ADK78_37515 | ADK78_32925 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pyridoxal-5'-phosphate-dependent protein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.998 |
KOG68273.1 | KOG69818.1 | ADK78_37515 | ADK78_31860 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aminoglycoside phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.916 |
KOG68273.1 | KOG72805.1 | ADK78_37515 | ADK78_18685 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.997 |
KOG68273.1 | KOG79106.1 | ADK78_37515 | ADK78_06745 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Molybdopterin biosynthesis-like protein MoeZ; The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; Derived by automated computational analysis using gene prediction method: Protein [...] | 0.994 |
KOG68273.1 | KOG79761.1 | ADK78_37515 | ADK78_05930 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
KOG68273.1 | KOG80819.1 | ADK78_37515 | ADK78_04575 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.881 |
KOG68273.1 | KOG81924.1 | ADK78_37515 | ADK78_03445 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine/threonine protein kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
KOG68273.1 | gcvP | ADK78_37515 | ADK78_02985 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |