KOG69648.1 protein (Kitasatospora aureofaciens)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

KOG69648.1

Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)

Predicted Functional Partners:

KOG77820.1

0.970

KOG69522.1

0.963

KOG69523.1

0.963

KOG82242.1

0.937

KOG73315.1

0.937

KOG84047.1

0.929

KOG80150.1

0.929

KOG74327.1

0.914

KOG69196.1

0.908

KOG70971.1

0.904

Your Current Organism:

Kitasatospora aureofaciens

NCBI taxonomy Id: 1894
Other names: ATCC 10762, ATCC 23884, BCRC 11610, CBS 434.51, CBS 664.68, CCRC 11610, CCRC:11610, CECT 3206, CIP 57.11, DSM 40127, HAMBI 313, HUT 6048, HUT 6097, ICMP 499, IFO 12594, IFO 12843, IFO 3712, ISP 5127, JCM 4008, JCM 4624, K. aureofaciens, KACC 20180, LMG 5968, LMG:5968, NBRC 12594, NBRC 12843, NBRC 3712, NCAIM B.01479, NCIMB 8234, NRRL 2209, NRRL B-5404, NRRL-ISP 5127, NRRL-ISP:5127, NRRL:B:5404, RIA 57, Streptomyces aureifaciens, Streptomyces aureofaciens, Streptomyces aureofaciens subsp. aureofaciens, VKM Ac-771

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KOG69196.1	KOG69648.1	ADK78_34410	ADK78_32500	Thiol-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.908
KOG69196.1	KOG73315.1	ADK78_34410	ADK78_17155	Thiol-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.700
KOG69196.1	KOG82242.1	ADK78_34410	ADK78_03205	Thiol-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.700
KOG69522.1	KOG69523.1	ADK78_32490	ADK78_32495	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
KOG69522.1	KOG69648.1	ADK78_32490	ADK78_32500	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.963
KOG69523.1	KOG69522.1	ADK78_32495	ADK78_32490	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
KOG69523.1	KOG69648.1	ADK78_32495	ADK78_32500	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.963
KOG69648.1	KOG69196.1	ADK78_32500	ADK78_34410	Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thiol-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.908
KOG69648.1	KOG69522.1	ADK78_32500	ADK78_32490	Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.963
KOG69648.1	KOG69523.1	ADK78_32500	ADK78_32495	Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.963
KOG69648.1	KOG70971.1	ADK78_32500	ADK78_26855	Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.904
KOG69648.1	KOG73315.1	ADK78_32500	ADK78_17155	Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.937
KOG69648.1	KOG74327.1	ADK78_32500	ADK78_14705	Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.914
KOG69648.1	KOG77820.1	ADK78_32500	ADK78_08500	Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.970
KOG69648.1	KOG80150.1	ADK78_32500	ADK78_05830	Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.929
KOG69648.1	KOG82242.1	ADK78_32500	ADK78_03205	Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.937
KOG69648.1	KOG84047.1	ADK78_32500	ADK78_00005	Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	DoxX family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.929
KOG70971.1	KOG69648.1	ADK78_26855	ADK78_32500	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.904
KOG70971.1	KOG73315.1	ADK78_26855	ADK78_17155	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KOG70971.1	KOG74327.1	ADK78_26855	ADK78_14705	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999

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Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.838

expected number of edges:

28

PPI enrichment p-value:

0.0102

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

4 of 55

1.41

0.88

0.0102

GO:0019843

rRNA binding

3 of 42

1.4

0.64

0.0459

GO:0003723

RNA binding

4 of 110

1.11

0.56

0.0459

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022625

Cytosolic large ribosomal subunit

4 of 23

1.78

1.88

7.73e-05

GO:0032991

Protein-containing complex

5 of 227

0.89

0.67

0.0036

GO:0005829

Cytosol

5 of 312

0.75

0.51

0.0117

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:26617599

(2015) Comparative Genomic Insights into Ecophysiology of Neutrophilic, Microaerophilic Iron Oxidizing Bacteria.

3 of 16

1.82

0.98

0.0117

PMID:28083017

(2016) Distribution of Hydrogenases in Cyanobacteria: A Phylum-Wide Genomic Survey.

3 of 19

1.74

0.97

0.0117

PMID:36545193

(2022) Characterizing corn-straw-degrading actinomycetes and evaluating application efficiency in straw-returning experiments.

3 of 29

1.56

0.83

0.0195

PMID:21936919

(2011) Genomic insights into an obligate epibiotic bacterial predator: Micavibrio aeruginosavorus ARL-13.

3 of 32

1.52

0.82

0.0195

PMID:19148287

(2009) Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum.

3 of 31

1.53

0.82

0.0195

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1368

HotDog domain superfamily, and Epoxide hydrolase-like

3 of 6

2.24

1.84

0.00030

CL:1322

Mixed, incl. Lipid oxidation, and Acyl-CoA dehydrogenase, middle domain

4 of 29

1.68

1.59

0.00030

CL:1250

Mixed, incl. Fatty acid metabolic process, and Carbon fixation pathways in prokaryotes

6 of 93

1.35

1.43

8.61e-05

CL:1252

Carbon fixation pathways in prokaryotes, and Fatty acid metabolic process

5 of 64

1.44

1.39

0.00028

CL:148

Cytosolic large ribosomal subunit, and Small ribosomal subunit

3 of 23

1.66

1.1

0.0050

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cau03010

Ribosome

4 of 55

1.41

1.15

0.0016

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0036125

Fatty acid beta-oxidation multienzyme complex

2 of 5

2.15

0.76

0.0393

GOCC:0022625

Cytosolic large ribosomal subunit

2 of 5

2.15

0.76

0.0393

GOCC:0005840

Ribosome

3 of 39

1.43

0.67

0.0393

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

4 of 53

1.42

1.09

0.0027

KW-0699

rRNA-binding

3 of 39

1.43

0.86

0.0130

KW-0276

Fatty acid metabolism

2 of 13

1.73

0.72

0.0398

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16113

Enoyl-CoA hydratase/isomerase

3 of 7

2.18

1.53

0.0012

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