STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LA_0127Hypothetical protein. (404 aa)    
Predicted Functional Partners:
hisB
Imidazoleglycerol-phosphate dehydratase or histidinol-phosphatase.
  
    0.753
hisH
Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
       0.751
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
       0.751
LA_0128
Hypothetical protein.
       0.720
LA_0129
Conserved hypothetical protein.
       0.617
LB_078
Thioredoxin domain-containing protein.
  
 
 0.567
LA_1321
Disulfide interchange transmembrane protein.
  
 
 0.561
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.481
LA_1958
Hypothetical protein.
 
 
 0.447
trxA
Thioredoxin.
 
 
 0.415
Your Current Organism:
Leptospira interrogans
NCBI taxonomy Id: 189518
Other names: L. interrogans serovar Lai str. 56601, Leptospira interrogans serovar Lai str. 56601
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.