| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cobQ | hisA | LB_151 | LA_0126 | Histidinol-phosphate aminotransferase and cobyric acid synthase; Catalyzes two activities which are involved in the adenosylcobalamin biosynthesis: decarboxylates L-threonine-O-3- phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin, and catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); In the N-terminal section; belongs to the class-II pyridox [...] | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.863 |
| cobQ | hisB | LB_151 | LA_0124 | Histidinol-phosphate aminotransferase and cobyric acid synthase; Catalyzes two activities which are involved in the adenosylcobalamin biosynthesis: decarboxylates L-threonine-O-3- phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin, and catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); In the N-terminal section; belongs to the class-II pyridox [...] | Imidazoleglycerol-phosphate dehydratase or histidinol-phosphatase. | 0.885 |
| cobQ | hisD | LB_151 | LA_2515 | Histidinol-phosphate aminotransferase and cobyric acid synthase; Catalyzes two activities which are involved in the adenosylcobalamin biosynthesis: decarboxylates L-threonine-O-3- phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin, and catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); In the N-terminal section; belongs to the class-II pyridox [...] | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.869 |
| cobQ | hisF | LB_151 | LA_2506 | Histidinol-phosphate aminotransferase and cobyric acid synthase; Catalyzes two activities which are involved in the adenosylcobalamin biosynthesis: decarboxylates L-threonine-O-3- phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin, and catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); In the N-terminal section; belongs to the class-II pyridox [...] | Imidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.863 |
| cobQ | hisG | LB_151 | LA_1262 | Histidinol-phosphate aminotransferase and cobyric acid synthase; Catalyzes two activities which are involved in the adenosylcobalamin biosynthesis: decarboxylates L-threonine-O-3- phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin, and catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); In the N-terminal section; belongs to the class-II pyridox [...] | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.879 |
| cobQ | hisH | LB_151 | LA_0125 | Histidinol-phosphate aminotransferase and cobyric acid synthase; Catalyzes two activities which are involved in the adenosylcobalamin biosynthesis: decarboxylates L-threonine-O-3- phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin, and catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); In the N-terminal section; belongs to the class-II pyridox [...] | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.863 |
| cobQ | hisI | LB_151 | LA_0551 | Histidinol-phosphate aminotransferase and cobyric acid synthase; Catalyzes two activities which are involved in the adenosylcobalamin biosynthesis: decarboxylates L-threonine-O-3- phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin, and catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); In the N-terminal section; belongs to the class-II pyridox [...] | phosphoribosyl-AMP cyclohydrolase protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.859 |
| cobQ | hisI-2 | LB_151 | LB_079 | Histidinol-phosphate aminotransferase and cobyric acid synthase; Catalyzes two activities which are involved in the adenosylcobalamin biosynthesis: decarboxylates L-threonine-O-3- phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin, and catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); In the N-terminal section; belongs to the class-II pyridox [...] | phosphoribosyl-ATP diphosphatase. | 0.858 |
| cobQ | hisZ | LB_151 | LA_1111 | Histidinol-phosphate aminotransferase and cobyric acid synthase; Catalyzes two activities which are involved in the adenosylcobalamin biosynthesis: decarboxylates L-threonine-O-3- phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin, and catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); In the N-terminal section; belongs to the class-II pyridox [...] | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity). | 0.826 |
| hisA | cobQ | LA_0126 | LB_151 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol-phosphate aminotransferase and cobyric acid synthase; Catalyzes two activities which are involved in the adenosylcobalamin biosynthesis: decarboxylates L-threonine-O-3- phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin, and catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); In the N-terminal section; belongs to the class-II pyridox [...] | 0.863 |
| hisA | hisB | LA_0126 | LA_0124 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate dehydratase or histidinol-phosphatase. | 0.997 |
| hisA | hisC | LA_0126 | LA_1182 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.888 |
| hisA | hisD | LA_0126 | LA_2515 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.993 |
| hisA | hisF | LA_0126 | LA_2506 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
| hisA | hisG | LA_0126 | LA_1262 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.983 |
| hisA | hisH | LA_0126 | LA_0125 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
| hisA | hisI | LA_0126 | LA_0551 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-AMP cyclohydrolase protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.998 |
| hisA | hisI-2 | LA_0126 | LB_079 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-ATP diphosphatase. | 0.983 |
| hisA | hisZ | LA_0126 | LA_1111 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity). | 0.944 |
| hisB | cobQ | LA_0124 | LB_151 | Imidazoleglycerol-phosphate dehydratase or histidinol-phosphatase. | Histidinol-phosphate aminotransferase and cobyric acid synthase; Catalyzes two activities which are involved in the adenosylcobalamin biosynthesis: decarboxylates L-threonine-O-3- phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin, and catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); In the N-terminal section; belongs to the class-II pyridox [...] | 0.885 |
