LA_0845 protein (Leptospira interrogans) - STRING interaction network

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Score

LA_0845

2-isopropylmalate synthase. (298 aa)

Predicted Functional Partners:

acs

0.933

LA_2689

0.922

paaJ-3

0.922

LA_4114

0.922

LA_4139

0.922

leuC

0.889

leuD

0.870

LA_0846

0.860

LA_3803

0.837

sucC

0.833

Your Current Organism:

Leptospira interrogans

NCBI taxonomy Id: 189518
Other names: L. interrogans serovar Lai str. 56601, Leptospira interrogans serovar Lai str. 56601

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LA_0845	LA_0846	LA_0845	LA_0846	2-isopropylmalate synthase.	Hypothetical protein.	0.860
LA_0845	LA_2689	LA_0845	LA_2689	2-isopropylmalate synthase.	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.922
LA_0845	LA_3803	LA_0845	LA_3803	2-isopropylmalate synthase.	acetyl-CoA carboxylase carboxyltransferase component.	0.837
LA_0845	LA_4114	LA_0845	LA_4114	2-isopropylmalate synthase.	Putative acetyl-CoA acetyltransferase.	0.922
LA_0845	LA_4139	LA_0845	LA_4139	2-isopropylmalate synthase.	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.922
LA_0845	acs	LA_0845	LA_1173	2-isopropylmalate synthase.	acetyl-CoA synthetase.	0.933
LA_0845	leuC	LA_0845	LA_2095	2-isopropylmalate synthase.	Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.889
LA_0845	leuD	LA_0845	LA_2096	2-isopropylmalate synthase.	3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.	0.870
LA_0845	paaJ-3	LA_0845	LA_3135	2-isopropylmalate synthase.	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.922
LA_0845	sucC	LA_0845	LA_1102	2-isopropylmalate synthase.	succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.833
LA_0846	LA_0845	LA_0846	LA_0845	Hypothetical protein.	2-isopropylmalate synthase.	0.860
LA_2689	LA_0845	LA_2689	LA_0845	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	2-isopropylmalate synthase.	0.922
LA_2689	LA_3803	LA_2689	LA_3803	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA carboxylase carboxyltransferase component.	0.512
LA_2689	LA_4114	LA_2689	LA_4114	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Putative acetyl-CoA acetyltransferase.	0.974
LA_2689	LA_4139	LA_2689	LA_4139	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.928
LA_2689	paaJ-3	LA_2689	LA_3135	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.900
LA_2689	sucC	LA_2689	LA_1102	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.881
LA_3803	LA_0845	LA_3803	LA_0845	acetyl-CoA carboxylase carboxyltransferase component.	2-isopropylmalate synthase.	0.837
LA_3803	LA_2689	LA_3803	LA_2689	acetyl-CoA carboxylase carboxyltransferase component.	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.512
LA_3803	LA_4114	LA_3803	LA_4114	acetyl-CoA carboxylase carboxyltransferase component.	Putative acetyl-CoA acetyltransferase.	0.469