Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
acoAPyruvate dehydrogenase alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (327 aa)    
Predicted Functional Partners:
aceF-2
Dihydrolipoamide acetyltransferase.
 
 0.999
acoB
Pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 0.999
lpd-3
Dihydrolipoamide dehydrogenase.
 
 
 0.982
lpd
Dihydrolipoamide dehydrogenase.
 
 
 0.978
aceF
Dihydrolipoamide acetyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
 0.975
sfcA
Malic enzyme.
  
 
 0.918
pykF
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 
 0.917
pykF-2
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 
 0.917
LA_2339
Biotin-requiring enzyme.
  
 0.899
lpd-2
Dihydrolipoamide dehydrogenase.
 
 
 0.891
Your Current Organism:
Leptospira interrogans
NCBI taxonomy Id: 189518
Other names: L. interrogans serovar Lai str. 56601, Leptospira interrogans serovar Lai str. 56601
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